Recruited renin-containing renal microvascular cells demonstrate the calcium paradox regulatory phenotype

Renin is the critical regulatory enzyme for production of angiotensin (Ang)-II, a potent vasoconstrictor involved in regulating blood pressure and in the pathogenesis of hypertension. Chronic sodium deprivation enhances renin secretion from the kidney, due to recruitment of additional cells from the...

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Bibliographic Details
Published in:Integrated blood pressure control 2014-01, Vol.7 (default), p.9-17
Main Authors: Macgriff, Spencer, Woo, Richard E, Ortiz-Capisano, M Cecilia, Atchison, Douglas K, Beierwaltes, William H
Format: Article
Language:English
Subjects:
Biological control systems
Blood pressure
Endocrine system
Enzymes
Ethanol
Genetic aspects
Genotype & phenotype
Health aspects
Hypertension
Kidneys
Laboratory animals
Nitric oxide
Original Research
Phenotype
Physiological aspects
Physiology
Renin
Smooth muscle
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Summary:Renin is the critical regulatory enzyme for production of angiotensin (Ang)-II, a potent vasoconstrictor involved in regulating blood pressure and in the pathogenesis of hypertension. Chronic sodium deprivation enhances renin secretion from the kidney, due to recruitment of additional cells from the afferent renal microvasculature to become renin-producing rather than just increasing release from existing juxtaglomerular (JG) cells. JG cells secrete renin inversely proportional to extra- and intracellular calcium, a unique phenomenon characteristic of the JG regulatory phenotype known as the "calcium paradox." It is not known if renin secreted from recruited renin-containing cells is regulated similarly to native JG cells, and therefore acquires this JG cell phenotype. We hypothesized that non-JG cells in renal microvessels recruited to produce renin in response to chronic dietary sodium restriction would demonstrate the calcium paradox, characteristic of the JG cell phenotype. Histology showed recruitment of upstream arteriolar renin in response to sodium restriction compared to normal-diet rats. Renin fluorescence intensity increased 53% in cortices of sodium-restricted rats (P
ISSN:1178-7104
1178-7104
DOI:10.2147/IBPC.S55684