Three New Indole Alkaloids from Tabernaemontana divaricata

Three new monoterpene indole alkaloids, 3 α -hydroxymethyl-ibogamine ( 1 ), 3 α -acetatemethoxyl-ibogamine ( 2 ), 16 α -hydroxyl-ibogamine ( 3 ) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids...

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Bibliographic Details
Published in:Natural products and bioprospecting 2018-06, Vol.8 (3), p.183-188
Main Authors: Deng, Yan, Bao, Mei-Fen, Shi, Bao-Bao, Wu, Jing, Cai, Xiang-Hai
Format: Article
Language:English
Subjects:
16α-hydroxyl-ibogamine
3α-acetatemethoxyl-ibogamine
3α-hydroxymethyl-ibogamine
Acetic acid
Alkaloids
Apocynaceae
Biomedical and Life Sciences
Bioorganic Chemistry
branches
Cancer
Carbon
cell lines
Cytotoxicity
Food Science
Gastric cancer
indole alkaloids
Indoles
inhibitory concentration 50
Laboratories
leaves
Life Sciences
Lung cancer
lung neoplasms
Medicinal Chemistry
Monoterpene indole alkaloids
monoterpenoids
Natural products
neoplasm cells
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
spectral analysis
stomach neoplasms
Tabernaemontana divaricata
Toxicity
Tumor cell lines
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Summary:Three new monoterpene indole alkaloids, 3 α -hydroxymethyl-ibogamine ( 1 ), 3 α -acetatemethoxyl-ibogamine ( 2 ), 16 α -hydroxyl-ibogamine ( 3 ) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC 50  > 20 µM). Graphical Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-018-0166-x