MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA–mRNA profile in QNBC patients based on race. Both miRNA and mRNA expression data were analyzed from TCGA and validated using dat...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.22178-14, Article 22178
Main Authors: Angajala, Anusha, Raymond, Hughley, Muhammad, Aliyu, Uddin Ahmed, Md Shakir, Haleema, Saadia, Haque, Monira, Wang, Honghe, Campbell, Moray, Martini, Rachel, Karanam, Balasubramanian, Kahn, Andrea G., Bedi, Deepa, Davis, Melissa, Tan, Ming, Dean-Colomb, Windy, Yates, Clayton
Format: Article
Language:English
Subjects:
631/114
631/250
631/337
631/67
631/80
692/4028
692/53
692/699
692/700
African Americans
Black or African American - genetics
Breast cancer
Breast Neoplasms - genetics
Data analysis
Datasets
Female
GATA-3 protein
Gene expression
Gene Expression Regulation, Neoplastic
Humanities and Social Sciences
Humans
Medical prognosis
Medical research
Medicine
Metadata
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Minority & ethnic groups
miRNA
multidisciplinary
Myc protein
Pathology
Proteomics
RNA, Messenger
Runx3 protein
Science
Science (multidisciplinary)
Software
Statistical analysis
Survival
Survival analysis
Triple Negative Breast Neoplasms - pathology
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA–mRNA profile in QNBC patients based on race. Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. miRNA–mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-26000-9