Anti-inflammatory and analgesic activities: Chemical constituents of essential oils of Ocimum gratissimum, Eucalyptus citriodora and Cymbopogon giganteus inhibited lipoxygenase L-1 and cyclooxygenase of PGHS

• Published in: Bulletin of the Chemical Society of Ethiopia 2003-12, Vol.17 (2), p.191-197
• Main Authors: Yao T. N’guessan, J.P. Mahy, C. Chopard, Z.F. Tonzibo, B. Boti, G. Bedi Sahouo
• Format: Article
• Language: English
• Subjects: C. giganteus (Poaceae); Cyclooxygenase function of prostaglandine H synthase-1; E. citriodora (Myrtaceae); Enantia chlorantha; Essential oils; Inhibition; O. gratissimum (Labiatae); PGHS; Soybean lipoxygenase (L-1)
• ISSN: 1011-3924; 1726-801X

The following studies report the inhibitory effect produced by chemical constituents of essential oils of three plants used in traditional medicine as anti-inflammatory and analgesic drugs, in vitro, on soybean lipoxygenase L-1 and cyclooxygenase function of prostaglandin H synthase (PGHS), the two enzymes involved in the production of mediators of inflammation. The essential oils were extracted from plants of three families: O. gratissimum (Labiatae), C. giganteus (Poaceae), and E. citriodora (Myrtaceae). Their chemical composition was established by GC/MS analyses. Among the three essential oils, one showed evident inhibition of L-1 with IC50 value of 72 μg/mL for Eucalyptus citriodora. Only one essential oil that of O. gratissimum inhibited the two enzymes, cyclooxygenase function of PGHS and lipoxygenase L-1, with an IC50 values, respectively, of 125 μg/mL and 144 μg/mL, whereas that of C. giganteus and E. citriodora, two of them had no effect on cyclooxygenase.