Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders

The aim of the present study was to analyse the effect of antiretroviral (ARV) therapy and single antiretroviral drugs on cerebrospinal fluid (CSF) HIV-RNA burden in HIV-infected patients affected by neurological disorders enrolled in a multicentric Italian cohort. ARVs were considered “neuroactive”...

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Published in:AIDS Research and Treatment 2012-01, Vol.2012 (2012), p.466-472, Article 708456
Main Authors: Lorenzini, Patrizia, Giancola, Maria Letizia, Cingolani, Antonella, Baldini, Francesco, Bossolasco, Simona, Bini, Teresa, Monno, Laura, Picchi, Giovanna, d’Arminio Monforte, Antonella, Cinque, Paola, Tozzi, Valerio, Antinori, Andrea
Format: Article
Language:English
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Neurological disorders
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Summary:The aim of the present study was to analyse the effect of antiretroviral (ARV) therapy and single antiretroviral drugs on cerebrospinal fluid (CSF) HIV-RNA burden in HIV-infected patients affected by neurological disorders enrolled in a multicentric Italian cohort. ARVs were considered “neuroactive” from literature reports. Three hundred sixty-three HIV-positive patients with available data from paired plasma and CSF samples, were selected. One hundred twenty patients (33.1%) were taking ARVs at diagnosis of neurological disorder. Mean CSF HIV-RNA was significantly higher in naïve than in experienced patients, and in patients not taking ARV than in those on ARV. A linear correlation between CSF HIV-RNA levels and number of neuroactive drugs included in the regimen was also found (r=−0.44, P
ISSN:2090-1240
2090-1259
2090-1259
DOI:10.1155/2012/708456