Vigilance Effects in Resting-State fMRI

Measures of resting-state functional magnetic resonance imaging (rsfMRI) activity have been shown to be sensitive to cognitive function and disease state. However, there is growing evidence that variations in vigilance can lead to pronounced and spatially widespread differences in resting-state brai...

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Bibliographic Details
Published in:Frontiers in neuroscience 2020-04, Vol.14, p.321-321
Main Authors: Liu, Thomas T, Falahpour, Maryam
Format: Article
Language:English
Subjects:
arousal
Brain mapping
Brain research
Caffeine
Cognitive ability
EEG
fMRI
functional connectivity
Functional magnetic resonance imaging
Neural networks
Neuroimaging
Neuroscience
Sleep
Sleep deprivation
Studies
Vigilance
wakefulness
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Summary:Measures of resting-state functional magnetic resonance imaging (rsfMRI) activity have been shown to be sensitive to cognitive function and disease state. However, there is growing evidence that variations in vigilance can lead to pronounced and spatially widespread differences in resting-state brain activity. Unless properly accounted for, differences in vigilance can give rise to changes in resting-state activity that can be misinterpreted as primary cognitive or disease-related effects. In this paper, we examine in detail the link between vigilance and rsfMRI measures, such as signal variance and functional connectivity. We consider how state changes due to factors such as caffeine and sleep deprivation affect both vigilance and rsfMRI measures and review emerging approaches and methodological challenges for the estimation and interpretation of vigilance effects.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2020.00321