Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells

Despite the promise of cancer medicine, major challenges currently confronting the treatment of cancer patients include chemoresistance and recurrence. The existence of subpopulations of cancer cells, known as cancer stem cells (CSCs), contributes to the failure of cancer therapies and is associated...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-07, Vol.9 (7), p.1691
Main Authors: Kim, Jungmin, Cheong, Jae-Ho
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - metabolism
Animals
Bioenergetics
Cancer
cancer metabolism
cancer mitochondria
cancer stem cell
Cancer therapies
Chemoresistance
Chemotherapy
Colorectal cancer
Cytoskeleton
Cytoskeleton - metabolism
cytoskeleton-mitochondria
Dehydrogenases
Drug resistance
Energy
Glycerol
Humans
Mesenchyme
Metabolism
Microtubules - metabolism
Mitochondria
Mitochondria - metabolism
Models, Biological
Morphology
Neoplastic Stem Cells - metabolism
Oxidation
Oxidative phosphorylation
Phosphorylation
Review
Stem cells
Structure-function relationships
Studies
tubulin
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the promise of cancer medicine, major challenges currently confronting the treatment of cancer patients include chemoresistance and recurrence. The existence of subpopulations of cancer cells, known as cancer stem cells (CSCs), contributes to the failure of cancer therapies and is associated with poor clinical outcomes. Of note, one of the recently characterized features of CSCs is augmented mitochondrial function. The cytoskeleton network is essential in regulating mitochondrial morphology and rearrangement, which are inextricably linked to its functions, such as oxidative phosphorylation (OXPHOS). The interaction between the cytoskeleton and mitochondria can enable CSCs to adapt to challenging conditions, such as a lack of energy sources, and to maintain their stemness. Cytoskeleton-mediated mitochondrial trafficking and relocating to the high energy requirement region are crucial steps in epithelial-to-mesenchymal transition (EMT). In addition, the cytoskeleton itself interplays with and blocks the voltage-dependent anion channel (VDAC) to directly regulate bioenergetics. In this review, we describe the regulation of cellular bioenergetics in CSCs, focusing on the cytoskeleton-mediated dynamic control of mitochondrial structure and function.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9071691