Influenza Virus Genomic Surveillance, Arizona, USA, 2023-2024

Influenza viruses are constantly evolving and are therefore monitored worldwide in the hope to reduce the burden of disease by annual updates to vaccine recommendations. We conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and Fe...

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Bibliographic Details
Published in:Viruses 2024-04, Vol.16 (5), p.692
Main Authors: Maqsood, Rabia, Smith, Matthew F, Holland, LaRinda A, Sullins, Regan A, Holland, Steven C, Tan, Michelle, Hernandez Barrera, Gabrielle M, Thomas, Alexis W, Islas, Mario, Kramer, Joanna L, Nordstrom, Lora, Mulrow, Mary, White, Michael, Murugan, Vel, Lim, Efrem S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Arizona
Arizona - epidemiology
Child
Child, Preschool
COVID-19 vaccines
Disease transmission
Drug resistance
Epidemiological Monitoring
Exo-a-sialidase
Female
Genes
Genetic engineering
Genome, Viral
Genomes
genomic surveillance
Genomics
Genomics - methods
Glycoproteins
Health aspects
Health services
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Hemagglutinins
Hispanic Americans
Humans
Influenza
Influenza A
Influenza A virus - classification
Influenza A virus - genetics
Influenza B
Influenza B virus - genetics
Influenza vaccines
Influenza Vaccines - genetics
Influenza Vaccines - immunology
influenza virus
Influenza, Human - epidemiology
Influenza, Human - virology
Lectins
Male
Middle Aged
Mutation
Neuraminidase - genetics
Pathogens
Phylogenetics
Phylogeny
Proteins
Public health
RNA
Severe acute respiratory syndrome coronavirus 2
Thermal cycling
Vaccination
Vaccine efficacy
Vaccines
Virulence
Viruses
Whole Genome Sequencing
Young Adult
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Description
Summary:Influenza viruses are constantly evolving and are therefore monitored worldwide in the hope to reduce the burden of disease by annual updates to vaccine recommendations. We conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and February 2024 in Arizona, USA. We identified mutations in the hemagglutinin (HA) antigenic sites as well as the neuraminidase (NA) gene in our samples. We also found no unique HA and NA mutations in vaccinated yet influenza-infected individuals. Real-time genomic sequencing surveillance is important to ensure influenza vaccine effectiveness.
ISSN:1999-4915
1999-4915
DOI:10.3390/v16050692