Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae)

Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities ha...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências 2016-10, Vol.88 (4), p.2229-2237
Main Authors: López, Kelvin S E, Marques, André M, Moreira, Davyson DE L, Velozo, Leosvaldo S, Sudo, Roberto T, Zapata-Sudo, Gisele, Guimarães, Elsie F, Kaplan, Maria Auxiliadora C
Format: Article
Language:English
Subjects:
amides
Amides - isolation & purification
anesthetic properties
Anesthetics, Local - isolation & purification
Animals
Benzodioxoles - isolation & purification
Brazil
Guinea Pigs
Hexanes - isolation & purification
MULTIDISCIPLINARY SCIENCES
Ottonia
Piper
Piperaceae
Piperaceae - chemistry
Plant Extracts - chemistry
Plant Roots - chemistry
sensory blockage
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Summary:Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as "anestesia" and it is a common habit of chewing leaves and roots of Ottonia species to relief toothache. The purpose of this study is to report our findings on new molecules entities obtained from the roots of Ottonia anisum Spreng, in which local anesthetic activity (sensory blockage) is demonstrated for the first time in vivo guinea pig model. Phytochemical investigation led to the isolation of three amides (pipercallosidine, piperine and valeramide) and in an enriched mixture of seven amides (valeramide, 4,5-dihydropiperlonguminine, N-isobutil-6-piperonil-2-hexenamide, piperovatine, dihydropipercallosidine, pipercallosidine and pipercallpsine). Our findings demonstrated the anesthetic potential for the methanolic extract from roots, its n-hexane partition and amides from O. anisum and it is in agreement with ethnobotanical survey.
ISSN:0001-3765
1678-2690
1678-2690
0001-3765
DOI:10.1590/0001-3765201620150821