Evaluation methods of a rat sciatic nerve crush injury model

The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards. This study aimed to investigate accurately assessment methods for research concerning the rat sciatic ne...

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Bibliographic Details
Published in:Journal of integrative neuroscience 2022-05, Vol.21 (3), p.91-91
Main Authors: An, Yun, Yan, Hui-Xin, Zhao, Jiang-Na, Yang, Xu-Ming, Yan, Jun-Tao
Format: Article
Language:English
Subjects:
Animals
Crush Injuries
neuroelectrophysiological
Peripheral Nerve Injuries
Rats
Sciatic Nerve - injuries
sciatic nerve crush injury
Sciatic Neuropathy
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Summary:The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards. This study aimed to investigate accurately assessment methods for research concerning the rat sciatic nerve crush injury. The sciatic nerve crush injury model of was performed using the FST toothless forceps. The corresponding locations and pressures of different ratchet strengths were assessed by using CMAP, behavioral, and morphological methods. In each group of PNI, motor and sensory functions were gradually restricted on the injured side of rats as the applied pressure increased. CMAP was more sensitive to nerve injury arising out of the force values obtained from the forceps. As a sensitive indicator for PNI, the neuroelectrophysiological examination was more likely to reflect the morphological changes of injured nerves. These findings may provide a standardized approach to sciatic crush injury modelling.
ISSN:0219-6352
DOI:10.31083/j.jin2103091