Anti-angiogenic peptides application in cancer therapy; a review

Cancer is a disease advanced via surplus angiogenesis. The development of new anti-angiogenic therapeutic agents with more efficacy and fewer side effects is still quite necessary. Conventional therapies saving the life of many cancer patients but due to drug resistance and lack of specificity utili...

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Bibliographic Details
Published in:Research in pharmaceutical sciences 2021-12, Vol.16 (6), p.559-574
Main Authors: Shoari, Alireza, Khodabakhsh, Farnaz, Ahangari Cohan, Reza, Salimian, Morteza, Karami, Elmira
Format: Article
Language:English
Subjects:
angiogenesis
cancer
nanobodies
natural resource
peptide
phage display
Antimitotic agents
Antineoplastic agents
Biological products
Chemical properties
Health aspects
Neovascularization
Peptides
Pharmaceutical research
Review
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Summary:Cancer is a disease advanced via surplus angiogenesis. The development of new anti-angiogenic therapeutic agents with more efficacy and fewer side effects is still quite necessary. Conventional therapies saving the life of many cancer patients but due to drug resistance and lack of specificity utilizing these methods is faced with limits. Recently, new therapeutic agents have been developed and used to treat cancers such as scaffold proteins, monoclonal antibodies, tyrosine kinase inhibitors, and peptides. In antiangiogenic drug development, anti-angiogenic peptides design is a significant aim. Peptides have developed as substantial therapeutics that are being carefully investigated in angiogenesis-dependent diseases because of their high penetrating rate into the cancer cells, high specificity, and low toxicity. In this review, we focus on anti-angiogenic peptides in the field of cancer therapy that are designed, screened, or derived from nanobodies, mimotopes, phage displays, and natural resources.
ISSN:1735-5362
1735-9414
DOI:10.4103/1735-5362.327503