Meta-analysis of incidence and outcomes of life-threatening arrhythmias in takotsubo cardiomyopathy

• Published in: Indian heart journal 2022-03, Vol.74 (2), p.110-119
• Main Authors: Rathore, Sawai Singh, Iqbal, Kinza, Shafqat, Shameel, Tariq, Eleze, Tousif, Sohaib, UlHaq, Zain Ghufran, Fernández-Sánchez, David, Hernández-Woodbine, María José, Granados-Mendoza, Sofia Carolina, Lacouture-Cárdenas, Natalia Andrea, Avendaño-Capriles, Camilo Andrés, Maheshwari, Chanchal, Iqbal, Aimen, Mahalwar, Gauranga, Shariff, Mariam, Kumar, Ashish
• Format: Article
• Language: English
• Subjects: Life-threatening arrhythmias; Mortality; Original; Takotsubo cardiomyopathy
• ISSN: 0019-4832; 2213-3763
• DOI: 10.1016/j.ihj.2022.01.005

Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is a transient heart condition that clinically resembles an acute coronary syndrome. This study aims to assess the incidence of life-threatening arrhythmias in patients with Takotsubo cardiomyopathy and evaluate the outcomes of patients with life-threatening arrhythmias (LTAs) in Takotsubo cardiomyopathy compared with those without LTA. We comprehensively searched the PubMed, Google Scholar, and Embase databases from inception to February 2021. The primary aim of the study was to determine the incidence of LTAs in TC patients. Other outcomes of interest were the odds of in-hospital, long-term mortality, and cardiogenic shock (CS) in TC patients with LTAs versus those without LTAs. For all statistical analyses, ReviewManager and MedCalc were used. Eighteen studies were included in this study involving 55,557 participants (2,185 with LTAs and 53,372 without LTAs). The pooled incidence of LTAs in the patients of TC was found to be 6.29% (CI: 4.70–8.08%; I2 = 94.67%). There was a statistically significant increased risk of in-hospital mortality (OR = 4.74; CI: 2.24–10.04; I2 = 77%, p