Cbl-b negatively regulates TLR/MyD88-mediated anti- Toxoplasma gondii immunity

This is the first report that a human E3 ubiquitin ligase, Casitas B-lineage lymphoma proto-oncogene B (Cbl-b), functions as a host dependency factor for the intracellular protozoan and the mechanism for how infection inhibits the TLR/MyD88 innate immunity pathway through MyD88 degradation mediated...

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Bibliographic Details
Published in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0007423-e0007423
Main Authors: Wei, Haixia, Wu, Shuizhen, Mai, Liying, Yang, Lili, Zou, Weihao, Peng, Hongjuan
Format: Article
Language:English
Subjects:
Cbl-b
Parasitology
Research Article
TLRs/MyD88
Toxoplasma gondii
ubiquitination
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Summary:This is the first report that a human E3 ubiquitin ligase, Casitas B-lineage lymphoma proto-oncogene B (Cbl-b), functions as a host dependency factor for the intracellular protozoan and the mechanism for how infection inhibits the TLR/MyD88 innate immunity pathway through MyD88 degradation mediated by Cbl-b. This finding is an impactful contribution for understanding the host cell immunity against infection.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.00074-23