Antibacterial Activity of Manganese Dioxide Nanosheets by ROS-Mediated Pathways and Destroying Membrane Integrity

Manganese dioxide (MnO2) nanosheets have shown exciting potential in nanomedicine because of their ultrathin thickness, large surface area, high near-infrared (NIR) absorbance and good biocompatibility. However, the effect of MnO2 nanosheets on bacteria is still unclear. In this study, MnO2 nanoshee...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2020-08, Vol.10 (8), p.1545
Main Authors: Du, Ting, Chen, Siya, Zhang, Jinyu, Li, Tingting, Li, Ping, Liu, Jifeng, Du, Xinjun, Wang, Shuo
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
antibacterial
Antibacterial activity
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Biocompatibility
destroy membrane integrity
Electrolytes
Fluorescence
Infections
Manganese
Manganese dioxide
Nanomaterials
Nanoparticles
Nanosheets
Nanotechnology
Near infrared radiation
Proteins
Public health
Reactive oxygen species
Salmonella
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Summary:Manganese dioxide (MnO2) nanosheets have shown exciting potential in nanomedicine because of their ultrathin thickness, large surface area, high near-infrared (NIR) absorbance and good biocompatibility. However, the effect of MnO2 nanosheets on bacteria is still unclear. In this study, MnO2 nanosheets were shown for the first time to possess highly efficient antibacterial activity by using Salmonella as a model pathogen. The growth curve and surface plate assay uncovered that 125 μg/mL MnO2 nanosheets could kill 99.2% of Salmonella, which was further verified by fluorescence-based live/dead staining measurement. Mechanism analysis indicated that MnO2 nanosheet treatment could dramatically induce reactive oxygen species production, increase ATPase activity and cause the leakage of electrolytes and protein contents, leading to bacterial death. These results uncover the previously undefined role of MnO2 nanosheets and provide novel strategies for developing antimicrobial agents.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano10081545