A Single Meal Containing Phytosterols Does Not Affect the Uptake or Tissue Distribution of Cholesterol in Zebrafish (Danio rerio)

Increased plant oil inclusion in aquaculture feeds has led to higher dietary phytosterol concentrations and speculation about whether this affects the metabolism and health of the fish. The mechanisms of cholesterol absorption and how phytosterols may affect this is unknown in fish. Zebrafish (Danio...

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Bibliographic Details
Published in:Frontiers in Marine Science 2019-03, Vol.6
Main Authors: van Spankeren, Michel, Sibinga, Nathaniel, Reinshol, Øyvind, Torstensen, Bente E., Sæle, Øystein, Liland, Nina S.
Format: Article
Language:English
Subjects:
Animal tissues
Aquaculture
Aquaculture feeds
Cholesterol
Cholesterol uptake
Danio rerio
Diet
Distribution
Excretion
Experiments
Fish
Freshwater fishes
Lipids
Metabolism
Nutrition research
Oils & fats
Phytosterols
Salmon
Sterols
Tissue
Uptake
Zebrafish
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Summary:Increased plant oil inclusion in aquaculture feeds has led to higher dietary phytosterol concentrations and speculation about whether this affects the metabolism and health of the fish. The mechanisms of cholesterol absorption and how phytosterols may affect this is unknown in fish. Zebrafish (Danio rerio) were used to study the effects of phytosterols on the uptake and organ distribution of dietary cholesterol in fish. One meal of diets containing a constant addition of cholesterol (cold and [4-14C] cholesterol) and varying types and concentrations of phytosterols were fed to fish in individual compartments. The fish were not previously conditioned on the experimental diets. Activity of 14C was then measured in water and fish tissues to quantify the tissue distribution and excretion of cholesterol. There were no effects of the moderate dietary concentrations of phytosterols on the excretion or tissue distribution of dietary cholesterol 24 hours after the meal.
ISSN:2296-7745
2296-7745
DOI:10.3389/fmars.2019.00092