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Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume
To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of ( ), a fresh sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2015 version), and HPLC-ESI-TOF/MS method was used to identify the chemical composi...
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| Published in: | Molecules (Basel, Switzerland) Switzerland), 2019-08, Vol.24 (17), p.3159 |
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| Main Authors: | , , , , , |
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| container_issue | 17 |
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| creator | Li, Yun Liu, Xiao-Qian Liu, Shan-Shan Liu, Da-Hui Wang, Xiao Wang, Zhi-Min |
| description | To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of
(
), a fresh
sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2015 version), and HPLC-ESI-TOF/MS method was used to identify the chemical composition in steamed and fresh
. Finally, 25 components were identified in
based on the characteristic fragments of the compounds and the changes of the 25 components of fresh and steamed
were compared by the relative content. Hydrolysis experiments and enzymatic hydrolysis experiments of 10 monomer compounds simulating the
steaming process were carried out for the first time. As a result, hydrolysis experiments proved that free gastrodin or
-hydroxybenzyl alcohol could be obtained by breaking ester bond or ether bond during the steaming process of
. Enzymatic experiments showed that steaming played an important role in the protection of gastrodin, confirming the hypothesis that steaming can promote the conversion of chemical constituents of
-inhibiting enzymatic degradation. This experiment clarified the scientific mechanism of the traditional steaming method of
and provided reference for how to apply
decoction to some extent. |
| doi_str_mv | 10.3390/molecules24173159 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7790806cb9464b13b9c90e2b56f7cc7d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_7790806cb9464b13b9c90e2b56f7cc7d</doaj_id><sourcerecordid>2333548739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-f400a13df12f89abd0f1d39ca36e96f8ae7c8136c3e706a9d4d94b0bf66ca4f73</originalsourceid><addsrcrecordid>eNplkt9rFDEQgBdRbK3-Ab7Igi--nObXJpsXwR62HlQUrK-G2WRylyOb1GRX8L_v2qul1aeEzDcfM5NpmpeUvOVck3djjmjniJUJqjjt9KPmmApGVpwI_fje_ah5VuueEEYF7Z42R5yKnjDeHTc_Lguk6nMZYQo5tZ_R7iCFOtY2-3a9wzFYiO0mbQu6gGmqbUjttwlhDGnbfi3ZYr1hz6FOJbsALUaYoD2N84jPmyceYsUXt-dJ8_3s4-X60-riy_lm_eFiZYXm08oLQoBy5ynzvYbBEU8d1xa4RC19D6hsT7m0HBWRoJ1wWgxk8FJaEF7xk2Zz8LoMe3NVwgjlt8kQzM1DLlsDZQo2olFKk55IO2ghxUD5oK0myIZOemWtcovr_cF1NQ8jOrs0XSA-kD6MpLAz2_zLSCUWJ1sEb24FJf-csU5mDNVijJAwz9Uw1ouuU0zTBX39D7rPc0nLqAzjnHeiV1wvFD1QtuRaC_q7YigxfzbB_LcJS86r-13cZfz9en4NCRWytA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2333548739</pqid></control><display><type>article</type><title>Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Li, Yun ; Liu, Xiao-Qian ; Liu, Shan-Shan ; Liu, Da-Hui ; Wang, Xiao ; Wang, Zhi-Min</creator><creatorcontrib>Li, Yun ; Liu, Xiao-Qian ; Liu, Shan-Shan ; Liu, Da-Hui ; Wang, Xiao ; Wang, Zhi-Min</creatorcontrib><description>To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of
(
), a fresh
sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2015 version), and HPLC-ESI-TOF/MS method was used to identify the chemical composition in steamed and fresh
. Finally, 25 components were identified in
based on the characteristic fragments of the compounds and the changes of the 25 components of fresh and steamed
were compared by the relative content. Hydrolysis experiments and enzymatic hydrolysis experiments of 10 monomer compounds simulating the
steaming process were carried out for the first time. As a result, hydrolysis experiments proved that free gastrodin or
-hydroxybenzyl alcohol could be obtained by breaking ester bond or ether bond during the steaming process of
. Enzymatic experiments showed that steaming played an important role in the protection of gastrodin, confirming the hypothesis that steaming can promote the conversion of chemical constituents of
-inhibiting enzymatic degradation. This experiment clarified the scientific mechanism of the traditional steaming method of
and provided reference for how to apply
decoction to some extent.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules24173159</identifier><identifier>PMID: 31480235</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alcohol ; Benzyl Alcohols - analysis ; Chinese medicine ; Chromatography, High Pressure Liquid - methods ; Dose-response effects ; Gastrodia - chemistry ; Gastrodia elata ; gastrodin ; Glucosides - analysis ; Glucosides - chemistry ; Hydrolysis ; Hypotheses ; Ingredients ; Mass spectrometry ; Mass spectroscopy ; Medical research ; Organic chemistry ; parishin A ; Pharmacology ; Quality assessment ; Researchers ; Spectrometry, Mass, Electrospray Ionization - methods ; Steam ; Steaming ; Tandem Mass Spectrometry</subject><ispartof>Molecules (Basel, Switzerland), 2019-08, Vol.24 (17), p.3159</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-f400a13df12f89abd0f1d39ca36e96f8ae7c8136c3e706a9d4d94b0bf66ca4f73</citedby><cites>FETCH-LOGICAL-c493t-f400a13df12f89abd0f1d39ca36e96f8ae7c8136c3e706a9d4d94b0bf66ca4f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2333548739/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2333548739?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31480235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Liu, Xiao-Qian</creatorcontrib><creatorcontrib>Liu, Shan-Shan</creatorcontrib><creatorcontrib>Liu, Da-Hui</creatorcontrib><creatorcontrib>Wang, Xiao</creatorcontrib><creatorcontrib>Wang, Zhi-Min</creatorcontrib><title>Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of
(
), a fresh
sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2015 version), and HPLC-ESI-TOF/MS method was used to identify the chemical composition in steamed and fresh
. Finally, 25 components were identified in
based on the characteristic fragments of the compounds and the changes of the 25 components of fresh and steamed
were compared by the relative content. Hydrolysis experiments and enzymatic hydrolysis experiments of 10 monomer compounds simulating the
steaming process were carried out for the first time. As a result, hydrolysis experiments proved that free gastrodin or
-hydroxybenzyl alcohol could be obtained by breaking ester bond or ether bond during the steaming process of
. Enzymatic experiments showed that steaming played an important role in the protection of gastrodin, confirming the hypothesis that steaming can promote the conversion of chemical constituents of
-inhibiting enzymatic degradation. This experiment clarified the scientific mechanism of the traditional steaming method of
and provided reference for how to apply
decoction to some extent.</description><subject>Alcohol</subject><subject>Benzyl Alcohols - analysis</subject><subject>Chinese medicine</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dose-response effects</subject><subject>Gastrodia - chemistry</subject><subject>Gastrodia elata</subject><subject>gastrodin</subject><subject>Glucosides - analysis</subject><subject>Glucosides - chemistry</subject><subject>Hydrolysis</subject><subject>Hypotheses</subject><subject>Ingredients</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical research</subject><subject>Organic chemistry</subject><subject>parishin A</subject><subject>Pharmacology</subject><subject>Quality assessment</subject><subject>Researchers</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Steam</subject><subject>Steaming</subject><subject>Tandem Mass Spectrometry</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNplkt9rFDEQgBdRbK3-Ab7Igi--nObXJpsXwR62HlQUrK-G2WRylyOb1GRX8L_v2qul1aeEzDcfM5NpmpeUvOVck3djjmjniJUJqjjt9KPmmApGVpwI_fje_ah5VuueEEYF7Z42R5yKnjDeHTc_Lguk6nMZYQo5tZ_R7iCFOtY2-3a9wzFYiO0mbQu6gGmqbUjttwlhDGnbfi3ZYr1hz6FOJbsALUaYoD2N84jPmyceYsUXt-dJ8_3s4-X60-riy_lm_eFiZYXm08oLQoBy5ynzvYbBEU8d1xa4RC19D6hsT7m0HBWRoJ1wWgxk8FJaEF7xk2Zz8LoMe3NVwgjlt8kQzM1DLlsDZQo2olFKk55IO2ghxUD5oK0myIZOemWtcovr_cF1NQ8jOrs0XSA-kD6MpLAz2_zLSCUWJ1sEb24FJf-csU5mDNVijJAwz9Uw1ouuU0zTBX39D7rPc0nLqAzjnHeiV1wvFD1QtuRaC_q7YigxfzbB_LcJS86r-13cZfz9en4NCRWytA</recordid><startdate>20190830</startdate><enddate>20190830</enddate><creator>Li, Yun</creator><creator>Liu, Xiao-Qian</creator><creator>Liu, Shan-Shan</creator><creator>Liu, Da-Hui</creator><creator>Wang, Xiao</creator><creator>Wang, Zhi-Min</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190830</creationdate><title>Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume</title><author>Li, Yun ; Liu, Xiao-Qian ; Liu, Shan-Shan ; Liu, Da-Hui ; Wang, Xiao ; Wang, Zhi-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-f400a13df12f89abd0f1d39ca36e96f8ae7c8136c3e706a9d4d94b0bf66ca4f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Benzyl Alcohols - analysis</topic><topic>Chinese medicine</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dose-response effects</topic><topic>Gastrodia - chemistry</topic><topic>Gastrodia elata</topic><topic>gastrodin</topic><topic>Glucosides - analysis</topic><topic>Glucosides - chemistry</topic><topic>Hydrolysis</topic><topic>Hypotheses</topic><topic>Ingredients</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medical research</topic><topic>Organic chemistry</topic><topic>parishin A</topic><topic>Pharmacology</topic><topic>Quality assessment</topic><topic>Researchers</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Steam</topic><topic>Steaming</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Liu, Xiao-Qian</creatorcontrib><creatorcontrib>Liu, Shan-Shan</creatorcontrib><creatorcontrib>Liu, Da-Hui</creatorcontrib><creatorcontrib>Wang, Xiao</creatorcontrib><creatorcontrib>Wang, Zhi-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yun</au><au>Liu, Xiao-Qian</au><au>Liu, Shan-Shan</au><au>Liu, Da-Hui</au><au>Wang, Xiao</au><au>Wang, Zhi-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2019-08-30</date><risdate>2019</risdate><volume>24</volume><issue>17</issue><spage>3159</spage><pages>3159-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of
(
), a fresh
sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2015 version), and HPLC-ESI-TOF/MS method was used to identify the chemical composition in steamed and fresh
. Finally, 25 components were identified in
based on the characteristic fragments of the compounds and the changes of the 25 components of fresh and steamed
were compared by the relative content. Hydrolysis experiments and enzymatic hydrolysis experiments of 10 monomer compounds simulating the
steaming process were carried out for the first time. As a result, hydrolysis experiments proved that free gastrodin or
-hydroxybenzyl alcohol could be obtained by breaking ester bond or ether bond during the steaming process of
. Enzymatic experiments showed that steaming played an important role in the protection of gastrodin, confirming the hypothesis that steaming can promote the conversion of chemical constituents of
-inhibiting enzymatic degradation. This experiment clarified the scientific mechanism of the traditional steaming method of
and provided reference for how to apply
decoction to some extent.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31480235</pmid><doi>10.3390/molecules24173159</doi><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Alcohol Benzyl Alcohols - analysis Chinese medicine Chromatography, High Pressure Liquid - methods Dose-response effects Gastrodia - chemistry Gastrodia elata gastrodin Glucosides - analysis Glucosides - chemistry Hydrolysis Hypotheses Ingredients Mass spectrometry Mass spectroscopy Medical research Organic chemistry parishin A Pharmacology Quality assessment Researchers Spectrometry, Mass, Electrospray Ionization - methods Steam Steaming Tandem Mass Spectrometry |
| title | Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume |
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