Programmed cell death disrupts inflammatory tumor microenvironment (TME) and promotes glioblastoma evolution

Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%. Therefore, it is important to understand the mechanism of treatment resistance and develop new anti-tumor strategies. Inductio...

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Bibliographic Details
Published in:Cell communication and signaling 2024-06, Vol.22 (1), p.333-14, Article 333
Main Authors: Liang, Tingyu, Gu, Lingui, Kang, Xiaoman, Li, Junlin, Song, Yixuan, Wang, Yu, Ma, Wenbin
Format: Article
Language:English
Subjects:
Animals
Antigens
Antimitotic agents
Antineoplastic agents
Apoptosis
Autophagy
Biochemistry
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain tumors
Cancer
Cancer therapies
Care and treatment
Cell death
Cytokines
Cytotoxicity
Diagnosis
Dosage and administration
Evolution
Ferroptosis
GBM
Glioblastoma
Glioblastoma - genetics
Glioblastoma - pathology
Glioblastoma multiforme
Glioma
Health aspects
Humans
Immunology
Inflammation
Inflammation - pathology
Inflammatory TME
Kinases
Lipid peroxidation
Lymphocytes
Medical prognosis
PCD
Prognosis
Relapse
Review
Treatment
Treatment resistance
Tumor cells
Tumor evolution
Tumor Microenvironment
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Summary:Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%. Therefore, it is important to understand the mechanism of treatment resistance and develop new anti-tumor strategies. Induction of programmed cell death (PCD) has become a promising anti-tumor strategy, but its effectiveness in treating GBM remains controversial. On the one hand, PCD triggers tumor cell death and then release mediators to draw in immune cells, creating a pro-inflammatory tumor microenvironment (TME). One the other hand, mounting evidence suggests that PCD and inflammatory TME will force tumor cells to evolve under survival stress, leading to tumor recurrence. The purpose of this review is to summarize the role of PCD and inflammatory TME in the tumor evolution of GBM and promising methods to overcome tumor evolution.
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-024-01602-0