Skin Recovery After Discontinuation of Long-Term Moisturizer Application: A Split-Face Comparison Pilot Study

Introduction Facial moisturizers are commonly used by healthy women and increasingly men of all age groups. This study aimed to investigate the effects of moisturizer discontinuation and the subsequent evolution of symptoms. Methods Two prospective observational split-face comparison pilot studies w...

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Bibliographic Details
Published in:Dermatology and therapy 2020-12, Vol.10 (6), p.1371-1382
Main Authors: Maul, Julia-Tatjana, Maul, Lara Valeska, Kägi, Marc, Cheng, Phil, Anzengruber, Florian, von Laue, Mathilde, Chen, Yuki, Kägi, Martin, Navarini, Alexander
Format: Article
Language:English
Subjects:
Care and treatment
Cutaneous manifestations of general diseases
Dermatology
Discontinuation
Dryness
Facial moisturizer
Health aspects
Internal Medicine
Long-term use
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Original Research
Patient outcomes
Plastic Surgery
Quality of Life Research
Skin
Skin care products
Women
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Summary:Introduction Facial moisturizers are commonly used by healthy women and increasingly men of all age groups. This study aimed to investigate the effects of moisturizer discontinuation and the subsequent evolution of symptoms. Methods Two prospective observational split-face comparison pilot studies were performed in Switzerland and enrolled (I) 20 healthy women aged 17–25 years in winter and (II) 36 female subjects 15–20 and 40–55 years of age in summer. Moisturizers were stopped on the investigational half of the face. On the control side, the usual skin care regimen was continued. Daily subjective (I/II) and objective (I) skin assessments for the occurrence of typical symptoms of dry skin (dryness, itching, scales, redness, wrinkles) were collected. Results In the winter study (cohort I) in both the subjective and objective assessment, all skin changes increased significantly within 1 day after discontinuation. On day 7, dryness ( p  
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-020-00453-0