Efficacy of faecal microbiota transplantation in Crohn’s disease: a new target treatment?

Summary The efficacy of faecal microbiota transplantation (FMT) in Crohn’s disease (CD) remains unclear due to lack of data. This study aimed to assess the value of FMT in treating CD‐related clinical targets. The use of FMT for CD as a registered trial (NCT01793831) was performed between October 20...

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Bibliographic Details
Published in:Microbial biotechnology 2020-05, Vol.13 (3), p.760-769
Main Authors: Xiang, Liyuan, Ding, Xiao, Li, Qianqian, Wu, Xia, Dai, Min, Long, Chuyan, He, Zhi, Cui, Bota, Zhang, Faming
Format: Article
Language:English
Subjects:
Abdomen
Adult
Age
Crohn Disease - therapy
Crohn's disease
Diarrhea
Fecal Microbiota Transplantation - standards
Female
Fever
Fistula
Fistulae
Humans
Male
Microbiota
Middle Aged
Pain
Patients
Remission
Steroids
Therapeutic applications
Transplantation
Treatment Outcome
Tumor necrosis factor-TNF
Young Adult
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Summary:Summary The efficacy of faecal microbiota transplantation (FMT) in Crohn’s disease (CD) remains unclear due to lack of data. This study aimed to assess the value of FMT in treating CD‐related clinical targets. The use of FMT for CD as a registered trial (NCT01793831) was performed between October 2012 and December 2017. Seven therapeutic targets included abdominal pain, diarrhoea, hematochezia, fever, steroid‐dependence, enterocutaneous fistula and active perianal fistula. Each target was recorded as 1 (yes) or 0 (no) during the long‐term follow‐up for each patient. The primary outcome was the rate of improvement in each therapeutic target. Overall, 174 patients completed the follow‐up. The median follow‐up duration was 43 (interquartile range, 28–59) months. The median score of the total targets was 2 (range, 1–4) before FMT, and it decreased significantly at 1, 3, 6, 12, 24 and 36 months after FMT (P 
ISSN:1751-7915
1751-7915
DOI:10.1111/1751-7915.13536