Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection

is a Gram-positive, spore-forming, toxin-producing anaerobe, and an important nosocomial pathogen. Due to the strictly anaerobic nature of the vegetative form, spores are the main morphotype of infection and transmission of the disease. Spore formation and their subsequent germination play critical...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2018-02, Vol.8, p.29-29
Main Authors: Zhu, Duolong, Sorg, Joseph A, Sun, Xingmin
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
C. difficile
CDI
Clostridium difficile - physiology
Clostridium Infections - drug therapy
Clostridium Infections - microbiology
Gene Expression Regulation, Bacterial
germination
Humans
Microbiology
Signal Transduction
spores
Spores, Bacterial - drug effects
sporulation
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Description
Summary:is a Gram-positive, spore-forming, toxin-producing anaerobe, and an important nosocomial pathogen. Due to the strictly anaerobic nature of the vegetative form, spores are the main morphotype of infection and transmission of the disease. Spore formation and their subsequent germination play critical roles in infection (CDI) progress. Under suitable conditions, spores will germinate and outgrow to produce the pathogenic vegetative form. During CDI, produces toxins (TcdA and TcdB) that are required to initiate the disease. Meanwhile, it also produces spores that are responsible for the persistence and recurrence of in patients. Recent studies have shed light on the regulatory mechanisms of sporulation and germination. This review is to summarize recent advances on the regulation of sporulation/germination in and the corresponding therapeutic strategies that are aimed at these important processes.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2018.00029