Coexistence of type 2 diabetes mellitus, arginine vasopressin deficiency, and Marfan syndrome: A case report

Diabetes mellitus (DM) and arginine vasopressin deficiency (AVP‐D) are characterized by polyuria. Marfan syndrome is an autosomal dominant disorder caused by pathogenetic variants in FBN1. Here, we report a patient with type 2 diabetes mellitus, AVP‐D, and Marfan syndrome. Although the coexistence o...

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Bibliographic Details
Published in:Journal of diabetes investigation 2024-07, Vol.15 (7), p.964-967
Main Authors: Le, Yunyi, Zhang, Jingjing, Hong, Tianpei, Yang, Jin
Format: Article
Language:English
Subjects:
Arginine Vasopressin - deficiency
Argipressin
Blood levels
Case Report
Case reports
Coexistence
Density
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Disease
Family medical history
Female
Fibrillin-1 - genetics
Genetic testing
Glucose
Hemoglobin
Hereditary diseases
Humans
Hyperglycemia
Insulin resistance
Magnetic resonance imaging
Male
Marfan syndrome
Marfan Syndrome - complications
Marfan Syndrome - genetics
Metabolism
Middle Aged
Patients
Peptides
Polyuria
Polyuria - complications
Polyuria - etiology
Thyroid gland
type 2 diabetes
Urine
Vasopressin
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Summary:Diabetes mellitus (DM) and arginine vasopressin deficiency (AVP‐D) are characterized by polyuria. Marfan syndrome is an autosomal dominant disorder caused by pathogenetic variants in FBN1. Here, we report a patient with type 2 diabetes mellitus, AVP‐D, and Marfan syndrome. Although the coexistence of type 2 diabetes mellitus and AVP‐D is rare, for those patients with type 2 diabetes mellitus, the existence of AVP‐D should be considered when polyuria is not in accordance with the blood glucose levels, especially for those with a low urine specific gravity. Specific symptoms or signs help to identify Marfan syndrome early, and genetic testing of the FBN1 pathogenetic variant helps to make a definitive diagnosis. For those patients with type 2 diabetes mellitus, the existence of arginine vasopressin deficiency should be considered when polyuria is not in accordance with the blood glucose levels, especially for those with a low urine specific gravity. Specific symptoms or signs help to identify Marfan syndrome early, and genetic testing of the FBN1 pathogenetic variant helps to make a definitive diagnosis.
ISSN:2040-1116
2040-1124
2040-1124
DOI:10.1111/jdi.14169