Subunit Vaccine Approaches for African Swine Fever Virus

African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus region in 2007, a highly virulent, genotype I...

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Bibliographic Details
Published in:Vaccines (Basel) 2019-06, Vol.7 (2), p.56
Main Authors: Gaudreault, Natasha N, Richt, Juergen A
Format: Article
Language:English
Subjects:
African swine fever
African swine fever virus
Animals
Antibodies
antibody dependent enhancement
Antigens
Asfarviridae
ASFV
disease enhancement
DNA viruses
Fever
Genotype & phenotype
Genotypes
Hogs
immunogens
Lymphocytes
protective immunity
Proteins
Review
subunit vaccines
Swine
Vaccines
Vectors (Biology)
Virulence
Viruses
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Description
Summary:African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus region in 2007, a highly virulent, genotype II strain of ASFV has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. This review summarizes various ASFV vaccine strategies that have been investigated, with focus on antigen-, DNA-, and virus vector-based vaccines. Known ASFV antigens and the determinants of protection against ASFV versus immunopathological enhancement of infection and disease are also discussed.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines7020056