Advanced Hydrogels Combined with Silver and Gold Nanoparticles against Antimicrobial Resistance

The development of multidrug-resistant (MDR) microorganisms has increased dramatically in the last decade as a natural consequence of the misuse and overuse of antimicrobials. The World Health Organization (WHO) recognizes that this is one of the top ten global public health threats facing humanity...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-01, Vol.12 (1), p.104
Main Authors: Moreno Ruiz, Yolice Patricia, de Almeida Campos, Luís André, Alves Agreles, Maria Andressa, Galembeck, André, Macário Ferro Cavalcanti, Isabella
Format: Article
Language:English
Subjects:
antibiofilm
antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
bacterial
Bacterial diseases
Bacterial infections
Biofilms
Catheters
Drug resistance
E coli
Enzymes
Gold
Health risks
hydrogel
Hydrogels
Medical equipment
Microorganisms
Multidrug resistance
Nanoparticles
Nanotechnology
Pathogens
Polyvinyl alcohol
Prostheses
Public health
Review
Silver
Staphylococcus infections
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Summary:The development of multidrug-resistant (MDR) microorganisms has increased dramatically in the last decade as a natural consequence of the misuse and overuse of antimicrobials. The World Health Organization (WHO) recognizes that this is one of the top ten global public health threats facing humanity today, demanding urgent multisectoral action. The UK government foresees that bacterial antimicrobial resistance (AMR) could kill 10 million people per year by 2050 worldwide. In this sense, metallic nanoparticles (NPs) have emerged as promising alternatives due to their outstanding antibacterial and antibiofilm properties. The efficient delivery of the NPs is also a matter of concern, and recent studies have demonstrated that hydrogels present an excellent ability to perform this task. The porous hydrogel structure with a high-water retention capability is a convenient host for the incorporation of the metallic nanoparticles, providing an efficient path to deliver the NPs properly reducing bacterial infections caused by MDR pathogenic microorganisms. This article reviews the most recent investigations on the characteristics, applications, advantages, and limitations of hydrogels combined with metallic NPs for treating MDR bacteria. The mechanisms of action and the antibiofilm activity of the NPs incorporated into hydrogels are also described. Finally, this contribution intends to fill some gaps in nanomedicine and serve as a guide for the development of advanced medical products.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12010104