Enhancement of the Antiobesity and Antioxidant Effect of Purple Sweet Potato Extracts and Enhancement of the Effects by Fermentation

The browning of white adipocytes, which transforms energy-storing white adipocytes to heat-producing beige adipocytes, is considered a strategy against metabolic diseases. Several dietary compounds, such as anthocyanins, flavonoids, and phenolic acids, induce a brown adipocyte-like phenotype in whit...

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Bibliographic Details
Published in:Antioxidants 2021-05, Vol.10 (6), p.888
Main Authors: Lee, Seul Gi, Chae, Jongbeom, Kim, Dong Se, Lee, Jung-Bok, Kwon, Gi-Seok, Kwon, Taeg Kyu, Nam, Ju-Ock
Format: Article
Language:English
Subjects:
3T3-L1 adipocyte
Adipocytes
Adipose tissue
Anthocyanins
antiobesity
Antioxidants
Body weight gain
browning
Diet
Fermentation
Flavonoids
Glucose
High fat diet
Ipomoea batatas
Lipolysis
Metabolic disorders
Metabolism
Mitochondria
Obesity
Phenolic acids
Phenotypes
Polymerase chain reaction
purple sweet potato
Reagents
Thermogenesis
transdifferentiation
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Summary:The browning of white adipocytes, which transforms energy-storing white adipocytes to heat-producing beige adipocytes, is considered a strategy against metabolic diseases. Several dietary compounds, such as anthocyanins, flavonoids, and phenolic acids, induce a brown adipocyte-like phenotype in white adipocytes. In this study, we demonstrated that purple sweet potato (Ipomoea batatas) extract (PSP) exhibited potent radical scavenging activity. In addition, PSP was found to contain large amounts of phenolic, flavonoid, and anthocyanin compounds; the amount of these compounds was affected by fermentation. Functionally, PSP-induced adipose browning in high-fat-diet (HFD)-induced obese mice. The administration of PSP significantly suppressed the body weight gain and abnormal expansion of white adipose tissues in the obese mice. The expression of adipose browning-related genes was higher in the inguinal white adipose tissues from the PSP-treated mice than those in the HFD-fed mice. Moreover, PSP-treated 3T3-L1 adipocytes formed multilocular lipid droplets, similar to those formed in the 3T3-L1 adipocytes treated with a browning induction cocktail. The PSP-treated cells had an increased expression level of mitochondria and lipolysis-related genes. The browning effects of PSP were enhanced by fermentation with Lactobacillus. This study, to our knowledge, is the first to identify a new mechanism to increase the antiobesity effects of PSP by inducing adipocyte browning of adipocytes.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10060888