Protective Effect of α-Lipoic Acid Against Arsenic Trioxide–Induced Acute Cardiac Toxicity in Rats

The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2011, Vol.115(2), pp.244-248
Main Authors: Kumazaki, Masafumi, Ando, Hitoshi, Sasaki, Akira, Koshimizu, Taka-aki, Ushijima, Kentarou, Hosohata, Keiko, Oshima, Yasuo, Fujimura, Akio
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - toxicity
Antioxidants - pharmacology
Antioxidants - toxicity
Arsenic Trioxide
Arsenicals
cardiac toxicity
Creatinine - blood
Death, Sudden, Cardiac - etiology
Death, Sudden, Cardiac - prevention & control
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - urine
Dose-Response Relationship, Drug
Electrocardiography - drug effects
Heart - drug effects
Oxidative Stress - drug effects
Oxides - toxicity
Protective Agents - pharmacology
Protective Agents - toxicity
Rats
Rats, Wistar
Thioctic Acid - pharmacology
Time Factors
Transaminases - blood
α-lipoic acid
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Summary:The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in combination with LA. In the acute study, continuous ECG recording revealed that intravenous injection of ATO caused transient ST-T change, whereas pretreatment with LA abolished the ATO-induced ECG abnormality in all animals. These results suggest that LA protects against the ATO-induced acute cardiac toxicity and subsequent sudden death in rats.
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.10280SC