Long-term prognosis of chronic total occlusion treated by successful percutaneous coronary intervention in patients with or without diabetes mellitus: a systematic review and meta-analysis

Diabetes mellitus (DM) is highly prevalent among patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Therefore, the purpose of our study was to investigate the clinical outcomes of CTO-PCI in patients with or without DM. All relevant articles published in...

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Bibliographic Details
Published in:Cardiovascular diabetology 2021-01, Vol.20 (1), p.29-29, Article 29
Main Authors: Zhu, Yong, Meng, Shuai, Chen, Maolin, Liu, Kesen, Jia, Ruofei, Li, Hong, Zhu, Huagang, Jin, Zening
Format: Article
Language:English
Subjects:
Angioplasty
Cardiovascular disease
Chronic total occlusions
Clinical outcomes
Coronary vessels
Diabetes
Diabetes mellitus
Drug delivery
Heart
Heart attacks
Implants
Intervention
Major adverse cardiac events
Medical prognosis
Medical treatment
Meta-analysis
Mortality
Occlusion
Original Investigation
Patients
Percutaneous coronary intervention
Prognosis
Risk factors
Software
Stents
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Summary:Diabetes mellitus (DM) is highly prevalent among patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Therefore, the purpose of our study was to investigate the clinical outcomes of CTO-PCI in patients with or without DM. All relevant articles published in electronic databases (PubMed, Embase, and the Cochrane Library) from inception to August 7, 2020 were identified with a comprehensive literature search. Additionally, we defined major adverse cardiac events (MACEs) as the primary endpoint and used risk ratios (RRs) with 95% confidence intervals (CIs) to express the pooled effects in this meta-analysis. Eleven studies consisting of 4238 DM patients and 5609 non-DM patients were included in our meta-analysis. For DM patients, successful CTO-PCI was associated with a significantly lower risk of MACEs (RR = 0.67, 95% CI 0.55-0.82, p = 0.0001), all-cause death (RR = 0.46, 95% CI 0.38-0.56, p 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-021-01223-8