Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers

Suicide is a leading cause of death worldwide, presenting a serious public health problem. We aimed to investigate the biological basis of suicide completion using proteomics on postmortem brain tissue. Thirty-six postmortem brain samples (23 suicide completers and 13 controls) were collected. We ev...

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Bibliographic Details
Published in:Translational psychiatry 2022-04, Vol.12 (1), p.142-142, Article 142
Main Authors: Kim, Min Ji, Do, Misol, Han, Dohyun, Son, Minsoo, Shin, Dongyoon, Yeo, Injoon, Yun, Young Hyun, Yoo, Seong Ho, Choi, Hyung Jin, Shin, Daun, Rhee, Sang Jin, Ahn, Yong Min, Kim, Youngsoo
Format: Article
Language:English
Subjects:
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Autopsies
Behavioral Sciences
Bioinformatics
Biological Psychology
Biomarkers
Brain - metabolism
Brain research
Chromatography, Liquid
Hospitals
Humans
Mass spectrometry
Medical schools
Medicine
Medicine & Public Health
Mental disorders
Neurosciences
Pharmacotherapy
Prefrontal Cortex - metabolism
Proteins
Proteomics
Psychiatrists
Psychiatry
Psychopathology
Scientific imaging
Suicide, Completed
Suicides & suicide attempts
University colleges
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Summary:Suicide is a leading cause of death worldwide, presenting a serious public health problem. We aimed to investigate the biological basis of suicide completion using proteomics on postmortem brain tissue. Thirty-six postmortem brain samples (23 suicide completers and 13 controls) were collected. We evaluated the proteomic profile in the prefrontal cortex (Broadmann area 9, 10) using tandem mass tag-based quantification with liquid chromatography–tandem mass spectrometry. Bioinformatics tools were used to elucidate the biological mechanisms related to suicide. Subgroup analysis was conducted to identify common differentially expressed proteins among clinically different groups. Of 9801 proteins identified, 295 were differentially expressed between groups. Suicide completion samples were mostly enriched in the endocannabinoid and apoptotic pathways (CAPNS1, CSNK2B, PTP4A2). Among the differentially expressed proteins, GSTT1 was identified as a potential biomarker among suicide completers with psychiatric disorders. Our findings suggest that the previously under-recognized endocannabinoid system and apoptotic processes are highly involved in suicide.
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-022-01896-z