A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases

Dyslipidaemias is the leading risk factor of several major cardiovascular diseases (CVDs), but there is still a lack of sufficient evidence supporting a causal role of lipoprotein subspecies in CVDs. In this study, we comprehensively investigated several lipoproteins and their subspecies, as well as...

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Bibliographic Details
Published in:Scientific reports 2024-05, Vol.14 (1), p.10645-9, Article 10645
Main Authors: Zheng, Rui, Lind, Lars
Format: Article
Language:English
Subjects:
692/4017
692/4019/2776
Aged
Apolipoprotein A-I - blood
Apolipoprotein A-I - genetics
Apolipoprotein B-100 - genetics
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cerebral infarction
Cholesterol
Cholesterol, HDL - blood
Congestive heart failure
Coronary artery disease
Coronary Disease - genetics
Female
Heart diseases
Heart Failure - genetics
High density lipoprotein
Humanities and Social Sciences
Humans
Investigations
Ischemia
Ischemic Stroke - blood
Ischemic Stroke - epidemiology
Ischemic Stroke - genetics
Lipoproteins
Magnetic Resonance Spectroscopy - methods
Male
Mendelian randomization
Mendelian Randomization Analysis
Metabolites
Metabolomics
Metabolomics - methods
Middle Aged
multidisciplinary
Myocardial infarction
NMR
Nuclear magnetic resonance
Risk Factors
Science
Science (multidisciplinary)
UK Biobank
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Summary:Dyslipidaemias is the leading risk factor of several major cardiovascular diseases (CVDs), but there is still a lack of sufficient evidence supporting a causal role of lipoprotein subspecies in CVDs. In this study, we comprehensively investigated several lipoproteins and their subspecies, as well as other metabolites, in relation to coronary heart disease (CHD), heart failure (HF) and ischemic stroke (IS) longitudinally and by Mendelian randomization (MR) leveraging NMR-measured metabolomic data from 118,012 UK Biobank participants. We found that 123, 110 and 36 analytes were longitudinally associated with myocardial infarction, HF and IS (FDR 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-61440-5