Prolonged postoperative ileus in gastric surgery: Is there any difference between laparoscopic and open surgery?

• Published in: Cancer medicine (Malden, MA) MA), 2019-09, Vol.8 (12), p.5515-5523
• Main Authors: Liang, Wenquan, Li, Jiyang, Zhang, Wang, Liu, Jie, Li, Mingsen, Gao, Yunhe, Wang, Ning, Cui, Jianxin, Zhang, Kecheng, Xi, Hongqing, Wei, Bo, Chen, Lin
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal surgery; Aged; Analgesics; Clinical Cancer Research; Consent; Data collection; Ethics; Female; Gastrectomy; Gastrectomy - adverse effects; Gastric cancer; gastric surgery; Humans; Ileus - epidemiology; Ileus - etiology; Intestine; laparoscopic surgery; Laparoscopy; Laparoscopy - adverse effects; Logistic Models; Male; Narcotics; open surgery; Opioids; Original Research; paralytic ileus; Patients; Postoperative Complications; Potassium; Potassium - blood; prolonged ileus; Regression analysis; Retrospective Studies; Risk Assessment; Risk Factors; Serum Albumin - analysis; Stomach Neoplasms - surgery; Studies; Surgery; Surgical techniques
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.2459

Background Prolonged postoperative ileus (PPOI) is a common complication after abdominal surgery, but data about risk factors of PPOI for patients with gastric cancer are rare. We sought to investigate the impact of laparoscopic versus open surgery for PPOI after gastric cancer surgery. Methods A retrospective cohort study was conducted using a registry database consecutively collected from June 2016 to March 2017. PPOI was defined as no bowel function persisting for more than 4 days. Univariate analysis and multiple logistic regression models were performed to investigate risk factors, and stratified analysis was carried out to examine the primary association at different levels of a potential confounding factor. Results A total of 162 patients composed of 63 patients undergoing laparotomy and 99 patients undergoing laparoscopy were enrolled and PPOI was observed in 32 (19.75%) patients. Risk factors significantly correlated with PPOI were as follows: open surgery, older age, late surgical pathologic staging, postoperative use of opioid analgesic, low level of postoperative albumin and serum potassium. Compared to open surgery, the laparoscopic surgery was a strong protective factor for PPOI after adjusting related variables (OR = 0.17, CI: 0.05‐0.52, P = .002). There was an interaction between surgical methods and the postoperative WBC level (P for interaction = .007). In the two group stratified analysis of WBC, laparoscopic surgery had a significant lower risk of PPOI than open group for the patients with WBC counts above the middle level in crude or adjusted models. This result remained significantly in the three group stratified analysis for the patients with WBC counts in the middle and or high tertile groups. Conclusions PPOI is a common postoperative complication of patients after gastrectomy. Laparoscopic surgery is associated with decreased risk of PPOI in gastric surgery. Patients who underwent open surgery and presented with high level of WBC should be cautious with PPOI. Stratified analyses of surgical approaches on PPOI showed that there was an interaction between surgical approaches and the subgroup of postoperative WBC.