Absence of GATA3/FOXA1 co-expression predicts poor prognosis in upper tract urothelial carcinoma

GATA binding protein 3 (GATA3) and forkhead box A1 (FOXA1) have been individually implicated in the progression of upper tract urothelial carcinoma (UTUC). This study aims to evaluate the prognostic value of GATA3/FOXA1 co-expression in UTUC patients. We collected 108 UTUC pathological tissue sample...

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Bibliographic Details
Published in:Frontiers in oncology 2024-02, Vol.14, p.1302864-1302864
Main Authors: Wang, Yue, Wang, Yunfan, He, Huiying, Xiong, Yan
Format: Article
Language:English
Subjects:
FoxA1
GATA3
necrosis
Oncology
prognosis
upper tract urothelial carcinoma
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Summary:GATA binding protein 3 (GATA3) and forkhead box A1 (FOXA1) have been individually implicated in the progression of upper tract urothelial carcinoma (UTUC). This study aims to evaluate the prognostic value of GATA3/FOXA1 co-expression in UTUC patients. We collected 108 UTUC pathological tissue samples with complete follow-up data and 24 normal control urothelial tissues. We created a 132-site microarray and performed immunohistochemistry (IHC) to measure GATA3 and FOXA1 expression levels. Kaplan-Meier survival and Cox regression analyses were conducted to assess UTUC prognosis. GATA3 expression was positively correlated with FOXA1 (P=0.031). Absence of GATA3/FOXA1 co-expression (GATA3-/FOXA1-) was associated with tumor extensive necrosis (P=0.001) after Bonferroni correction for multiple comparisons. GATA3-/FOXA1- was associated with shorter Disease-Free Survival (DFS) (P=0.001) and Cancer-Specific Survival (CSS) (P
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1302864