Dissecting myocardial mechanics in patients with severe aortic stenosis: 2-dimensional vs 3-dimensional-speckle tracking echocardiography

Aortic stenosis (AS) causes left ventricular (LV) pressure overload, leading to adverse LV remodeling and dysfunction. Identifying early subclinical markers of LV dysfunction in patients with significant AS is critical as this could provide support for earlier intervention, which may result in impro...

Full description

Saved in:
Bibliographic Details
Published in:BMC cardiovascular disorders 2020-01, Vol.20 (1), p.33-33, Article 33
Main Authors: Bi, Xiaojun, Yeung, Darwin F, Salah, Husam M, Arciniegas Calle, Maria C, Thaden, Jeremy J, Nhola, Lara F, Schaff, Hartzell V, Pislaru, Sorin V, Pellikka, Patricia A, Pochettino, Alberto, Greason, Kevin L, Nkomo, Vuyisile T, Villarraga, Hector R
Format: Article
Language:English
Subjects:
Agreements
Aortic stenosis
Aortic valve stenosis
Cardiac patients
Cardiovascular disease
Complications and side effects
Echocardiography
Health aspects
Heart
Left ventricular function
Measurement
Myocardial mechanics
Software
Speckle-tracking echocardiography
Stenosis
Strain
Three dimensional imaging
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aortic stenosis (AS) causes left ventricular (LV) pressure overload, leading to adverse LV remodeling and dysfunction. Identifying early subclinical markers of LV dysfunction in patients with significant AS is critical as this could provide support for earlier intervention, which may result in improved long-term outcomes. We therefore examined the impact of severe AS and its consequent increase in LV afterload on myocardial deformation and rotational mechanics by 2-dimensional (2D) and 3-dimensional (3D) speckle-tracking echocardiography. We prospectively measured various strain parameters in 168 patients (42% female, mean age 72 ± 12 years) with severe AS and LV ejection fraction (EF) ≥50%, and compared them to normal values found in literature. 2D and 3D images were analyzed for global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), basal rotation, apical rotation, and peak systolic twist. We further assessed the degree of concordance between 2D and 3D strain, and examined their association with measures of LV preload and afterload. Patients with severe AS exhibited significantly lower GLS and GRS but higher GCS, apical rotation, and twist by 2D and 3D echocardiography compared with published normal values (P = 0.003 for 3D twist, P 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-020-01336-0