Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients

To compare chemoradiotherapy (CRT) with low-dose continuous 5-fluorouracil (5FU) to CRT with 5FU+cisplatin (CDDP) for esophageal squamous cell carcinoma (ESCC) in a retrospective cohort study. We reviewed the cases of Stage I–IV ESCC patients who underwent definitive CRT in 2000–2014. Concomitant ch...

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Bibliographic Details
Published in:Clinical and translational radiation oncology 2018-02, Vol.9 (C), p.12-17
Main Authors: Saito, Hirotake, Ohta, Atsushi, Abe, Eisuke, Kaidu, Motoki, Shioi, Miki, Nakano, Toshimichi, Oshikane, Tomoya, Tanaka, Kensuke, Maruyama, Katsuya, Kushima, Naotaka, Tanabe, Satoshi, Utsunomiya, Satoru, Sasamoto, Ryuta, Aoyama, Hidefumi
Format: Article
Language:English
Subjects:
5-Fluorouracil
Chemoradiotherapy
Cisplatin
Esophageal cancer
Hematological toxicity
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Summary:To compare chemoradiotherapy (CRT) with low-dose continuous 5-fluorouracil (5FU) to CRT with 5FU+cisplatin (CDDP) for esophageal squamous cell carcinoma (ESCC) in a retrospective cohort study. We reviewed the cases of Stage I–IV ESCC patients who underwent definitive CRT in 2000–2014. Concomitant chemotherapy was one of the three regimens: (1) high-dose intermittent 5FU and CDDP (standard-dose FP: SDFP), (2) low-dose continuous 5FU and CDDP (LDFP), or (3) low-dose continuous 5FU (LD5FU). The general selection criteria for chemotherapy were: SDFP for patients aged
ISSN:2405-6308
2405-6308
DOI:10.1016/j.ctro.2017.12.003