Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients

• Published in: BJC reports 2024-01, Vol.2 (1), p.63-12, Article 63
• Main Authors: Wesselink, Evertine, Gauderman, William, Berndt, Sonja I, Brenner, Hermann, Buchanan, Daniel D, Campbell, Peter T, Chan, Andrew T, Chang-Claude, Jenny, Cotterchoi, Michelle, Gunter, Marc J, Hoffmeister, Michael, Joshi, Amit D, Newton, Christina C, Pai, Rish K, Pellatt, Andrew J, Phipps, Amanda I, Song, Mingyang, Um, Caroline Y, van Guelpen, Bethany, White, Emily, Peters, Ulrike, van Duijnhoven, Fränzel J B
• Format: Article
• Language: English
• ISSN: 2731-9377; 2731-9377
• DOI: 10.1038/s44276-024-00077-3

Research on calcium intake as well as variants in the calcium sensor receptor ( gene and their interaction in relation to CRC survival is still limited. Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary (  = 13.085), supplemental (  = 11,837), total calcium intake (  = 5970) as well as 325 single nucleotide polymorphisms (SNPs) of the gene (  = 15,734) in relation to CRC-specific and all-cause mortality were assessed using Cox proportional hazard models. Also interactions between calcium intake and variants in the gene were assessed. During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92-1.09), supplemental (HR 0.97, 95%CI 0.89-1.06) and total calcium intake (HR 0.99, 95%CI 0.88-1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the gene. Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the gene.