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Bacterial Blood Stream Infections Negatively Impact on Outcome of Patients Treated with Allogeneic Stem Cell Transplantation: 6 Years Single-Centre Experience
Blood stream infections (BSIs) represent a major complication of allo-SCT and are a major cause of morbidity and mortality during and after bone marrow aplasia. The objective of this study was to describe the incidence and outcome of BSIs in a cohort of patients submitted to allo-SCT, in order to tr...
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Published in: | Mediterranean journal of hematology and infectious diseases 2017-06, Vol.9 (1), p.e2017036-e2017036 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Blood stream infections (BSIs) represent a major complication of allo-SCT and are a major cause of morbidity and mortality during and after bone marrow aplasia.
The objective of this study was to describe the incidence and outcome of BSIs in a cohort of patients submitted to allo-SCT, in order to track changes of the epidemiology and bacteria resistance.
We retrospectively analyzed the microbiological data of 162 patients allotransplanted in Brescia University Hospital, over a period of 6 years.
Eighty patients experienced a BSIs for a total of 119 isolates. In 77 cases (65%) a Gram positive bacteria was isolated, being coagulase negative
the most frequent species (77% of the cases). In 42 cases (35%) a Gram negative bacteria was isolated (
.
57% and P.
24%). Fluoroquinolones resistance was frequent (90% for
, 92% for E.
, 90% for
). Methycillin resistance of
was 100%, 76% of
were ESBL positive and among
resistance to carbapenems was 40%. The 2 years overall survival of patients with BSIs
patients without BSIs was 46% vs 60% (HR1,48, p=0,07).
and
were the species with the highest mortality (50% and 33%, respectively).
These data confirm that BSIs, mainly sustained by Gram positive bacteria, are frequent in allotransplanted patients (50% of the cases) and may influence the outcome of allotransplanted patients, being antibiotics resistance highly frequent among these bacteria. |
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ISSN: | 2035-3006 2035-3006 |
DOI: | 10.4084/MJHID.2017.036 |