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Bacterial Blood Stream Infections Negatively Impact on Outcome of Patients Treated with Allogeneic Stem Cell Transplantation: 6 Years Single-Centre Experience

Blood stream infections (BSIs) represent a major complication of allo-SCT and are a major cause of morbidity and mortality during and after bone marrow aplasia. The objective of this study was to describe the incidence and outcome of BSIs in a cohort of patients submitted to allo-SCT, in order to tr...

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Published in:Mediterranean journal of hematology and infectious diseases 2017-06, Vol.9 (1), p.e2017036-e2017036
Main Authors: Malagola, Michele, Rambaldi, Bendetta, Ravizzola, Giuseppe, Cattaneo, Chiara, Borlenghi, Erika, Polverelli, Nicola, Turra, Alessandro, Morello, Enrico, Skert, Cristina, Cancelli, Valeria, Cattina, Federica, Giannetta, Giorgio, Bernardi, Simona, Perucca, Simone, Almici, Camillo, Roccaro, Aldo, Signorini, Liana, Stellini, Roberto, Castelli, Francesco, Caruso, Arnaldo, Russo, Domenico
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Language:English
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Summary:Blood stream infections (BSIs) represent a major complication of allo-SCT and are a major cause of morbidity and mortality during and after bone marrow aplasia. The objective of this study was to describe the incidence and outcome of BSIs in a cohort of patients submitted to allo-SCT, in order to track changes of the epidemiology and bacteria resistance. We retrospectively analyzed the microbiological data of 162 patients allotransplanted in Brescia University Hospital, over a period of 6 years. Eighty patients experienced a BSIs for a total of 119 isolates. In 77 cases (65%) a Gram positive bacteria was isolated, being coagulase negative the most frequent species (77% of the cases). In 42 cases (35%) a Gram negative bacteria was isolated ( . 57% and P. 24%). Fluoroquinolones resistance was frequent (90% for , 92% for E. , 90% for ). Methycillin resistance of was 100%, 76% of were ESBL positive and among resistance to carbapenems was 40%. The 2 years overall survival of patients with BSIs patients without BSIs was 46% vs 60% (HR1,48, p=0,07). and were the species with the highest mortality (50% and 33%, respectively). These data confirm that BSIs, mainly sustained by Gram positive bacteria, are frequent in allotransplanted patients (50% of the cases) and may influence the outcome of allotransplanted patients, being antibiotics resistance highly frequent among these bacteria.
ISSN:2035-3006
2035-3006
DOI:10.4084/MJHID.2017.036