Clinical correlation between N-terminal pro-b-type natriuretic peptide and angiographic coronary atherosclerosis

This study aimed to investigate the clinical correlation between angiographic coronary atherosclerosis and N-terminal pro-B-type natriuretic peptide along with other known correlated factors. In total, 153 patients with a diagnostic hypothesis of stable angina, unstable angina or acute myocardial in...

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Published in:Clinics (São Paulo, Brazil) Brazil), 2014-06, Vol.69 (6), p.405-412
Main Authors: Ribeiro, Demóstenes G.L., Silva, Ricardo P., Barboza, Daniella R.M.M., Lima-Júnior, Roberto C.P., Ribeiro, Ronaldo A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - diagnostic imaging
Biomarkers - blood
C-Reactive Protein - analysis
Clinical Science
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Female
Fibrinogen - analysis
Humans
Male
MEDICINE, GENERAL & INTERNAL
Middle Aged
Natriuretic Peptide, Brain - blood
NT-proBNP
Peptide Fragments - blood
Risk Factors
Severity of Illness Index
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description This study aimed to investigate the clinical correlation between angiographic coronary atherosclerosis and N-terminal pro-B-type natriuretic peptide along with other known correlated factors. In total, 153 patients with a diagnostic hypothesis of stable angina, unstable angina or acute myocardial infarction were classified as group A (patients with angiographically normal coronary arteries) or group B (patients with angiographic coronary atherosclerosis). The two groups were analyzed with respect to the following factors: gender, age, body mass index, abdominal circumference, smoking, diabetes mellitus, arterial hypertension, early family history of atherosclerosis, statin use, the presence of metabolic syndrome, clinical presentation and biochemical factors, including cholesterol, creatinine and fibrinogen plasma concentrations, monocyte counts and N-terminal pro-B-type natriuretic peptide. Univariate analyses comparing the two groups revealed that group B patients more frequently had diabetes, used statins and had systolic dysfunction, N-terminal pro-B-type natriuretic peptide levels ≥250 pg/mL, fibrinogen levels >500 mg/dL and ≥501 monocytes/mm3 compared with group A patients (p
doi_str_mv 10.6061/clinics/2014(06)07
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In total, 153 patients with a diagnostic hypothesis of stable angina, unstable angina or acute myocardial infarction were classified as group A (patients with angiographically normal coronary arteries) or group B (patients with angiographic coronary atherosclerosis). The two groups were analyzed with respect to the following factors: gender, age, body mass index, abdominal circumference, smoking, diabetes mellitus, arterial hypertension, early family history of atherosclerosis, statin use, the presence of metabolic syndrome, clinical presentation and biochemical factors, including cholesterol, creatinine and fibrinogen plasma concentrations, monocyte counts and N-terminal pro-B-type natriuretic peptide. Univariate analyses comparing the two groups revealed that group B patients more frequently had diabetes, used statins and had systolic dysfunction, N-terminal pro-B-type natriuretic peptide levels ≥250 pg/mL, fibrinogen levels &gt;500 mg/dL and ≥501 monocytes/mm3 compared with group A patients (p&lt;0.05). Nevertheless, multivariate logistic regression analysis demonstrated that the independent predictors of angiographic coronary atherosclerosis were an N-terminal pro-B-type natriuretic peptide level ≥250 pg/mL, diabetes mellitus and increased monocyte numbers and fibrinogen plasma concentration, regardless of the creatinine level or the presence of systolic dysfunction. 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In total, 153 patients with a diagnostic hypothesis of stable angina, unstable angina or acute myocardial infarction were classified as group A (patients with angiographically normal coronary arteries) or group B (patients with angiographic coronary atherosclerosis). The two groups were analyzed with respect to the following factors: gender, age, body mass index, abdominal circumference, smoking, diabetes mellitus, arterial hypertension, early family history of atherosclerosis, statin use, the presence of metabolic syndrome, clinical presentation and biochemical factors, including cholesterol, creatinine and fibrinogen plasma concentrations, monocyte counts and N-terminal pro-B-type natriuretic peptide. Univariate analyses comparing the two groups revealed that group B patients more frequently had diabetes, used statins and had systolic dysfunction, N-terminal pro-B-type natriuretic peptide levels ≥250 pg/mL, fibrinogen levels &gt;500 mg/dL and ≥501 monocytes/mm3 compared with group A patients (p&lt;0.05). Nevertheless, multivariate logistic regression analysis demonstrated that the independent predictors of angiographic coronary atherosclerosis were an N-terminal pro-B-type natriuretic peptide level ≥250 pg/mL, diabetes mellitus and increased monocyte numbers and fibrinogen plasma concentration, regardless of the creatinine level or the presence of systolic dysfunction. 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subjects Adult
Aged
Aged, 80 and over
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - diagnostic imaging
Biomarkers - blood
C-Reactive Protein - analysis
Clinical Science
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Female
Fibrinogen - analysis
Humans
Male
MEDICINE, GENERAL & INTERNAL
Middle Aged
Natriuretic Peptide, Brain - blood
NT-proBNP
Peptide Fragments - blood
Risk Factors
Severity of Illness Index
title Clinical correlation between N-terminal pro-b-type natriuretic peptide and angiographic coronary atherosclerosis
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