Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-...

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Bibliographic Details
Published in:Antioxidants 2020-09, Vol.9 (9), p.791
Main Authors: Vong, Long Binh, Nagasaki, Yukio
Format: Article
Language:English
Subjects:
Angiogenesis
Calcium phosphates
Cancer
Cancer therapies
Cardiovascular diseases
Care and treatment
Cell growth
Controlled release
Drug delivery
Drug delivery systems
Drug development
drug resistance
Drugs
Endothelium
gaseous signaling molecule
Growth factors
Health aspects
Light
Medical innovations
Multidrug resistance
Nanoparticles
Nitrates
Nitric oxide
Physiology
Review
self-assembled nanomedicine
Skin
Ultrasonic imaging
Vehicles
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Summary:Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects. To overcome the drawbacks of using this gaseous signaling molecule, researchers in the last several decades have focused on innovative medical technologies, specifically nanoparticle-based drug delivery systems (DDSs), because these systems alter the biodistribution of the therapeutic agent through controlled release at the target tissues, resulting in a significant therapeutic drug effect. Thus, the application of nano-systems for NO delivery in the field of biomedicine, particularly in the development of new drugs for cancer treatment, has been increasing worldwide. In this review, we discuss NO delivery nanoparticle systems, with the aim of improving drug delivery development for conventional chemotherapies and controlling multidrug resistance in cancer treatments.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9090791