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Genetic polymorphisms of fecundity genes in Watish Sudanese desert sheep
The Watish sheep is a strain of desert sheep of smaller size compared to other desert sheep ecotypes, and there is anecdotal evidence that it is endowed with high litter size. The present study was designed for screening for polymorphisms in the known fecundity genes (bone morphogenetic protein rece...
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Published in: | Veterinary World 2020-04, Vol.13 (4), p.614-621 |
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creator | Mohamed, Sara E Ibrahim Ahmed, Romaz M Jawasreh, Khaleel I Z Salih, M A M Abdelhalim, Dalia Mursi Abdelgadir, A W Obeidat, Md T Musa, L M A Ahmed, Mohammed-Khair A |
description | The Watish sheep is a strain of desert sheep of smaller size compared to other desert sheep ecotypes, and there is anecdotal evidence that it is endowed with high litter size. The present study was designed for screening for polymorphisms in the known fecundity genes (bone morphogenetic protein receptor type 1B A |
doi_str_mv | 10.14202/vetworld.2020.614-621 |
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fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_784dcd9520f64e2fa76de7b012c46e9d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A624517812</galeid><doaj_id>oai_doaj_org_article_784dcd9520f64e2fa76de7b012c46e9d</doaj_id><sourcerecordid>A624517812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c575t-c0d3fa8be86aadeefe7fd59543c175cfa7abbee52ecc60c0f15d734cffec752c3</originalsourceid><addsrcrecordid>eNptkk1r3DAQhk1paZY0fyEYeunFW0nWh30phNAmgUAOaelRyNJoV4ttbSU7Yf99Z7NJ2i2VQEKjdx5phrcozilZUs4I-_wA02NMvVvigSwl5ZVk9E2xYKymFWmpfFssSKtY1bRNc1Kc5bwhODhhLRPvi5OaCS5bUi-K6ysYYQq23MZ-N8S0XYc85DL60oOdRxemXblCSS7DWP40U8jr8n52BiNQOlzSVOY1wPZD8c6bPsPZ835a_Pj29fvldXV7d3VzeXFbWaHEVFniam-aDhppjAPwoLwTreC1pUpYb5TpOgDBwFpJLPFUOFVz6_E7SjBbnxY3B66LZqO3KQwm7XQ0QT8FYlppk7CgHrRquLOuFYx4yYEhWzpQHaHMcgmtQ9aXA2s7dwM4C-OUTH8EPb4Zw1qv4oNWjAtFCAI-PQNS_DVDnvQQsoW-x_7EOWvGKeeUsYah9OM_0k2c04it0qxuZa1II8Qf1cpgAWH0Ed-1e6i-kPgoVQ3ds5b_UeF0MAQbR_AB40cJ8pBgU8w5gX-tkRL9ZCn9Yim9t5RGS2m0FCae_92h17QXA9W_AQhNyrY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2396370855</pqid></control><display><type>article</type><title>Genetic polymorphisms of fecundity genes in Watish Sudanese desert sheep</title><source>PubMed (Medline)</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><creator>Mohamed, Sara E Ibrahim ; Ahmed, Romaz M ; Jawasreh, Khaleel I Z ; Salih, M A M ; Abdelhalim, Dalia Mursi ; Abdelgadir, A W ; Obeidat, Md T ; Musa, L M A ; Ahmed, Mohammed-Khair A</creator><creatorcontrib>Mohamed, Sara E Ibrahim ; Ahmed, Romaz M ; Jawasreh, Khaleel I Z ; Salih, M A M ; Abdelhalim, Dalia Mursi ; Abdelgadir, A W ; Obeidat, Md T ; Musa, L M A ; Ahmed, Mohammed-Khair A</creatorcontrib><description>The Watish sheep is a strain of desert sheep of smaller size compared to other desert sheep ecotypes, and there is anecdotal evidence that it is endowed with high litter size. The present study was designed for screening for polymorphisms in the known fecundity genes (bone morphogenetic protein receptor type 1B A<G in exon 6, bone morphogenetic protein 15 (
) (
,
,
, and
) in exon2, growth differentiation factor 9 (
) - G1 in exon1 and G8 in exon2 and PRLG<A in intron2) and their association with litter size in Watish.
The study involved 156 Watish ewes of 2-6 years of age, along with data on litter size in the first, second, and third parity from Sinnar state and contiguous Blue Nile State. Genomic DNA was isolated and genotyped using polymerase chain reaction-restriction fragment length polymorphism. Allele and genotype frequencies were calculated by direct counting. Chi-square test for goodness of fit was performed for agreement with Hardy-Weinberg expectations and association testing.
The results demonstrated that all individuals were non-carriers for the target mutations of
,
(
, and
), and
-G8. With regard to the
-G1 gene, the genotypic frequencies were 0.07% (G+) and 0.93% (++), in
gene they were 0.993% (++) and 0.006% (B+), in
gene 0.516(++), 0.347(B+), and 0.137(BB). The Chi-square test showed a non-significant association between ewe's type of birth and the detected mutations genotypes.
These results preliminarily indicated that
-G1,
(
), and
genes might have had some contribution for improving litter size in Watish Sudanese sheep. However, further studies using larger samples are needed to detect the effects of those mutations on Watish sheep litter size.</description><identifier>ISSN: 0972-8988</identifier><identifier>EISSN: 2231-0916</identifier><identifier>DOI: 10.14202/vetworld.2020.614-621</identifier><identifier>PMID: 32546903</identifier><language>eng</language><publisher>India: Veterinary World</publisher><subject>Bone morphogenetic proteins ; Comparative analysis ; DNA ; Ecotypes ; Fecundity ; G1 gene ; Gene frequency ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic research ; Genotypes ; Growth differentiation factor 9 ; Litter size ; Mutation ; Polymerase chain reaction ; Restriction fragment length polymorphism ; Sheep ; watish</subject><ispartof>Veterinary World, 2020-04, Vol.13 (4), p.614-621</ispartof><rights>Copyright: © Mohamed, et al.</rights><rights>COPYRIGHT 2020 Veterinary World</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © Mohamed, . 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-c0d3fa8be86aadeefe7fd59543c175cfa7abbee52ecc60c0f15d734cffec752c3</citedby><cites>FETCH-LOGICAL-c575t-c0d3fa8be86aadeefe7fd59543c175cfa7abbee52ecc60c0f15d734cffec752c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245700/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2396370855?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32546903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, Sara E Ibrahim</creatorcontrib><creatorcontrib>Ahmed, Romaz M</creatorcontrib><creatorcontrib>Jawasreh, Khaleel I Z</creatorcontrib><creatorcontrib>Salih, M A M</creatorcontrib><creatorcontrib>Abdelhalim, Dalia Mursi</creatorcontrib><creatorcontrib>Abdelgadir, A W</creatorcontrib><creatorcontrib>Obeidat, Md T</creatorcontrib><creatorcontrib>Musa, L M A</creatorcontrib><creatorcontrib>Ahmed, Mohammed-Khair A</creatorcontrib><title>Genetic polymorphisms of fecundity genes in Watish Sudanese desert sheep</title><title>Veterinary World</title><addtitle>Vet World</addtitle><description>The Watish sheep is a strain of desert sheep of smaller size compared to other desert sheep ecotypes, and there is anecdotal evidence that it is endowed with high litter size. The present study was designed for screening for polymorphisms in the known fecundity genes (bone morphogenetic protein receptor type 1B A<G in exon 6, bone morphogenetic protein 15 (
) (
,
,
, and
) in exon2, growth differentiation factor 9 (
) - G1 in exon1 and G8 in exon2 and PRLG<A in intron2) and their association with litter size in Watish.
The study involved 156 Watish ewes of 2-6 years of age, along with data on litter size in the first, second, and third parity from Sinnar state and contiguous Blue Nile State. Genomic DNA was isolated and genotyped using polymerase chain reaction-restriction fragment length polymorphism. Allele and genotype frequencies were calculated by direct counting. Chi-square test for goodness of fit was performed for agreement with Hardy-Weinberg expectations and association testing.
The results demonstrated that all individuals were non-carriers for the target mutations of
,
(
, and
), and
-G8. With regard to the
-G1 gene, the genotypic frequencies were 0.07% (G+) and 0.93% (++), in
gene they were 0.993% (++) and 0.006% (B+), in
gene 0.516(++), 0.347(B+), and 0.137(BB). The Chi-square test showed a non-significant association between ewe's type of birth and the detected mutations genotypes.
These results preliminarily indicated that
-G1,
(
), and
genes might have had some contribution for improving litter size in Watish Sudanese sheep. However, further studies using larger samples are needed to detect the effects of those mutations on Watish sheep litter size.</description><subject>Bone morphogenetic proteins</subject><subject>Comparative analysis</subject><subject>DNA</subject><subject>Ecotypes</subject><subject>Fecundity</subject><subject>G1 gene</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic research</subject><subject>Genotypes</subject><subject>Growth differentiation factor 9</subject><subject>Litter size</subject><subject>Mutation</subject><subject>Polymerase chain reaction</subject><subject>Restriction fragment length polymorphism</subject><subject>Sheep</subject><subject>watish</subject><issn>0972-8988</issn><issn>2231-0916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1r3DAQhk1paZY0fyEYeunFW0nWh30phNAmgUAOaelRyNJoV4ttbSU7Yf99Z7NJ2i2VQEKjdx5phrcozilZUs4I-_wA02NMvVvigSwl5ZVk9E2xYKymFWmpfFssSKtY1bRNc1Kc5bwhODhhLRPvi5OaCS5bUi-K6ysYYQq23MZ-N8S0XYc85DL60oOdRxemXblCSS7DWP40U8jr8n52BiNQOlzSVOY1wPZD8c6bPsPZ835a_Pj29fvldXV7d3VzeXFbWaHEVFniam-aDhppjAPwoLwTreC1pUpYb5TpOgDBwFpJLPFUOFVz6_E7SjBbnxY3B66LZqO3KQwm7XQ0QT8FYlppk7CgHrRquLOuFYx4yYEhWzpQHaHMcgmtQ9aXA2s7dwM4C-OUTH8EPb4Zw1qv4oNWjAtFCAI-PQNS_DVDnvQQsoW-x_7EOWvGKeeUsYah9OM_0k2c04it0qxuZa1II8Qf1cpgAWH0Ed-1e6i-kPgoVQ3ds5b_UeF0MAQbR_AB40cJ8pBgU8w5gX-tkRL9ZCn9Yim9t5RGS2m0FCae_92h17QXA9W_AQhNyrY</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Mohamed, Sara E Ibrahim</creator><creator>Ahmed, Romaz M</creator><creator>Jawasreh, Khaleel I Z</creator><creator>Salih, M A M</creator><creator>Abdelhalim, Dalia Mursi</creator><creator>Abdelgadir, A W</creator><creator>Obeidat, Md T</creator><creator>Musa, L M A</creator><creator>Ahmed, Mohammed-Khair A</creator><general>Veterinary World</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L.-</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200401</creationdate><title>Genetic polymorphisms of fecundity genes in Watish Sudanese desert sheep</title><author>Mohamed, Sara E Ibrahim ; Ahmed, Romaz M ; Jawasreh, Khaleel I Z ; Salih, M A M ; Abdelhalim, Dalia Mursi ; Abdelgadir, A W ; Obeidat, Md T ; Musa, L M A ; Ahmed, Mohammed-Khair A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-c0d3fa8be86aadeefe7fd59543c175cfa7abbee52ecc60c0f15d734cffec752c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bone morphogenetic proteins</topic><topic>Comparative analysis</topic><topic>DNA</topic><topic>Ecotypes</topic><topic>Fecundity</topic><topic>G1 gene</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic research</topic><topic>Genotypes</topic><topic>Growth differentiation factor 9</topic><topic>Litter size</topic><topic>Mutation</topic><topic>Polymerase chain reaction</topic><topic>Restriction fragment length polymorphism</topic><topic>Sheep</topic><topic>watish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Sara E Ibrahim</creatorcontrib><creatorcontrib>Ahmed, Romaz M</creatorcontrib><creatorcontrib>Jawasreh, Khaleel I Z</creatorcontrib><creatorcontrib>Salih, M A M</creatorcontrib><creatorcontrib>Abdelhalim, Dalia Mursi</creatorcontrib><creatorcontrib>Abdelgadir, A W</creatorcontrib><creatorcontrib>Obeidat, Md T</creatorcontrib><creatorcontrib>Musa, L M A</creatorcontrib><creatorcontrib>Ahmed, Mohammed-Khair A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science & Technology</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Veterinary World</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, Sara E Ibrahim</au><au>Ahmed, Romaz M</au><au>Jawasreh, Khaleel I Z</au><au>Salih, M A M</au><au>Abdelhalim, Dalia Mursi</au><au>Abdelgadir, A W</au><au>Obeidat, Md T</au><au>Musa, L M A</au><au>Ahmed, Mohammed-Khair A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphisms of fecundity genes in Watish Sudanese desert sheep</atitle><jtitle>Veterinary World</jtitle><addtitle>Vet World</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>13</volume><issue>4</issue><spage>614</spage><epage>621</epage><pages>614-621</pages><issn>0972-8988</issn><eissn>2231-0916</eissn><abstract>The Watish sheep is a strain of desert sheep of smaller size compared to other desert sheep ecotypes, and there is anecdotal evidence that it is endowed with high litter size. The present study was designed for screening for polymorphisms in the known fecundity genes (bone morphogenetic protein receptor type 1B A<G in exon 6, bone morphogenetic protein 15 (
) (
,
,
, and
) in exon2, growth differentiation factor 9 (
) - G1 in exon1 and G8 in exon2 and PRLG<A in intron2) and their association with litter size in Watish.
The study involved 156 Watish ewes of 2-6 years of age, along with data on litter size in the first, second, and third parity from Sinnar state and contiguous Blue Nile State. Genomic DNA was isolated and genotyped using polymerase chain reaction-restriction fragment length polymorphism. Allele and genotype frequencies were calculated by direct counting. Chi-square test for goodness of fit was performed for agreement with Hardy-Weinberg expectations and association testing.
The results demonstrated that all individuals were non-carriers for the target mutations of
,
(
, and
), and
-G8. With regard to the
-G1 gene, the genotypic frequencies were 0.07% (G+) and 0.93% (++), in
gene they were 0.993% (++) and 0.006% (B+), in
gene 0.516(++), 0.347(B+), and 0.137(BB). The Chi-square test showed a non-significant association between ewe's type of birth and the detected mutations genotypes.
These results preliminarily indicated that
-G1,
(
), and
genes might have had some contribution for improving litter size in Watish Sudanese sheep. However, further studies using larger samples are needed to detect the effects of those mutations on Watish sheep litter size.</abstract><cop>India</cop><pub>Veterinary World</pub><pmid>32546903</pmid><doi>10.14202/vetworld.2020.614-621</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Bone morphogenetic proteins Comparative analysis DNA Ecotypes Fecundity G1 gene Gene frequency Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genetic research Genotypes Growth differentiation factor 9 Litter size Mutation Polymerase chain reaction Restriction fragment length polymorphism Sheep watish |
title | Genetic polymorphisms of fecundity genes in Watish Sudanese desert sheep |
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