Sarcoidosis mimicking primary sclerosing cholangitis requiring liver transplantation

Sarcoidosis is a systemic granulomatous disease of unknown etiology. The association of the cholestatic pattern usually seen in sarcoidosis, with biliary duct changes resembling primary sclerosing cholangitis (PSC) is rare. Liver transplantation permits the histological evaluation of the complete ex...

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Bibliographic Details
Published in:Annals of hepatology 2008-01, Vol.7 (1), p.83-86
Main Authors: Tombazzi, Claudio, Waters, Bradford, Ismail, Mohammad K, Sylvestre, Pamela B, Martinez-Hernandez, Antonio, Riely, Caroline A
Format: Article
Language:English
Subjects:
Adult
Bile Ducts - pathology
biliary stricture
Cholangiography
Cholangitis, Sclerosing - diagnostic imaging
Cholangitis, Sclerosing - pathology
Cholestasis
Diagnosis, Differential
Female
granulomas
Humans
Liver Transplantation
Middle Aged
Sarcoidosis - diagnostic imaging
Sarcoidosis - pathology
Sarcoidosis - surgery
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Description
Summary:Sarcoidosis is a systemic granulomatous disease of unknown etiology. The association of the cholestatic pattern usually seen in sarcoidosis, with biliary duct changes resembling primary sclerosing cholangitis (PSC) is rare. Liver transplantation permits the histological evaluation of the complete explanted liver, making the diagnosis more reliable. In conclusion we present our experience with two patients with sarcoidosis requiring liver transplantation, who presented with clinical and radiological findings characteristics of primary sclerosing cholangitis.
ISSN:1665-2681
DOI:10.1016/s1665-2681(19)31894-0