Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study

• Published in: Frontiers in cardiovascular medicine 2022-11, Vol.9, p.1046839-1046839
• Main Authors: Yuan, Yujuan, Ma, Yiping, Aili, Zulipiya, Nijiati, Muyesai
• Format: Article
• Language: English
• Subjects: acute myocardial infarction (AMI); Cardiovascular Medicine; coronary blood; microparticles (MPs); miR-126; thrombosis; TIMI score
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2022.1046839

Acute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed to investigate the changes in Extracellular vesicle (EV)-associated miR-126 levels in the coronary blood of patients with AMI to explore the relationship between miR-126 levels and AMI. We analyzed EV-associated miR-126 in the coronary blood of patients with AMI and stable coronary artery disease (SCAD) using quantitative reverse transcription polymerase chain reaction (qRT-PCR). We tested the coronary blood of 20 patients with AMI and 20 with SCAD. The mean age of the patients was 58.8 ± 10.3 years and 32 (80%) were men. We observed that the EV-associated miR-126 levels were lower in patients with AMI [median = 0.13; interquartile range (IQR): 0.08-0.22] than in patients with SCAD (median = 0.37; IQR: 0.26-0.48) ( < 0.001). In addition, the levels of miR-126 were negatively associated with the Thrombolysis in Myocardial Infarction (TIMI) score ( = -0.66, = 0.001). Reduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events.