Degradable Magnesium and Its Surface Modification as Tumor Embolic Agent for Transcatheter Arterial Chemoembolization

Transcatheter arterial chemoembolization (TACE) is an effective method for traditional cancer treatment. Currently, various embolic agents block the blood vessels in the TACE operation. In this paper, the feasibility of the degradable Mg applied for TACE was explored innovatively. The degradation be...

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Bibliographic Details
Published in:Crystals (Basel) 2023-01, Vol.13 (2), p.194
Main Authors: Kang, Xinbao, Wang, Yonggang, Li, Hongtao, Yu, Han, Zhang, Xiyue, Zan, Rui, Wang, Wenhui, Wang, Tao, Zhang, Xiaonong
Format: Article
Language:English
Subjects:
Biocompatibility
biodegradable
Blood vessels
Cancer
Cancer therapies
Care and treatment
Colorectal cancer
Contrast agents
Contrast media
corrosion
Corrosion and anti-corrosives
Corrosion products
Corrosion resistance
Degradation
Drug therapy
Feasibility
Fractures
Hemangioma
Liver cancer
Magnesium
Magnesium alloys
Medical research
Medical technology
Oxidation
Patients
PLLA
Protective coatings
transcatheter arterial chemoembolization
Transplants & implants
Tumors
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Summary:Transcatheter arterial chemoembolization (TACE) is an effective method for traditional cancer treatment. Currently, various embolic agents block the blood vessels in the TACE operation. In this paper, the feasibility of the degradable Mg applied for TACE was explored innovatively. The degradation behavior of Mg particles and PLLA modified Mg particles used as embolic agents in contrast media was studied. The morphology and corrosion products were also characterized. After two days of immersion, the pH of the contrast agent was increased to 9.79 and 10.28 by the PLLA-modified Mg particles and unmodified Mg, respectively. The results show that the surface-modified Mg particles with PLLA have an eligible degradation rate to release degradation products and form an acceptable microenvironment. It is feasible to be used as an embolic agent in TACE.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst13020194