Association between Oral vitamin C supplementation and serum uric acid: A meta-analysis of randomized controlled trials

•This is an updated meta-analysis to explore the association between oral vitamin C supplementation and serum uric acid.•The results of this study show that vitamin C supplementation had a significant effect of lowering serum uric acid.•The use of placebo, duration of intervention, age of the subjec...

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Bibliographic Details
Published in:Complementary therapies in medicine 2021-08, Vol.60, p.102761-102761, Article 102761
Main Authors: Liu, Xin-xin, Wang, Xiao-xue, Cui, Ling-ling
Format: Article
Language:English
Subjects:
Age
Ascorbic acid
Bias
Clinical trials
Collaboration
Confidence intervals
Diabetes
Dietary supplements
Disease
Heterogeneity
Meta-analysis
Metabolic syndrome
Placebos
RCTs
Rheumatism
Sensitivity analysis
Serum uric acid
Standard deviation
Statistical analysis
Subgroups
Systematic review
Uric acid
Vitamin C
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Summary:•This is an updated meta-analysis to explore the association between oral vitamin C supplementation and serum uric acid.•The results of this study show that vitamin C supplementation had a significant effect of lowering serum uric acid.•The use of placebo, duration of intervention, age of the subjects and study quality have an impact on the effect of oral vitamin C. Results from recent trials assessing the effect of oral vitamin C supplementation on serum uric acid (SUA) have been inconsistent. The purpose of this study was to explore the association between oral vitamin C supplementation and serum uric acid. PUBMED, EMBASE, CNKI, Web of Science, and CENTRAL of Cochrane library databases were searched to identify relevant articles published up to February 2020. Heterogeneity was evaluated using I-square (I2) statistics. Random-effects model was used to pool weighted mean differences (WMD) and 95 % confidence interval (CI) as summary effect sizes. The total sixteen eligible randomized controlled trials (RCTs) containing 1,013 participants were included in this meta-analysis. The pooled findings showed that vitamin C supplementation had a significant effect of lowering SUA. The subgroup analyses showed that the effect of vitamin C supplementation on SUA has positive association with mean age of participants
ISSN:0965-2299
1873-6963
DOI:10.1016/j.ctim.2021.102761