Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis

High-mobility group box 1 (HMGB1) is a proinflammatory cytokine that plays an active role during the pathogenesis of inflammatory processes. The primary aim of this study was to detect whether HMGB1 is involved in the pathogenesis of acute obstructive suppurative cholangitis (AOSC). We collected per...

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Published in:Journal of inflammation research 2015-01, Vol.8 (default), p.71-77
Main Authors: Singh, Akanand, Feng, Yi, Mahato, Nisha, Li, Jinzheng, Wu, Chuanxin, Gong, Jianping
Format: Article
Language:English
Subjects:
AOSC
Appendicitis
Cholangitis
Chromosomal proteins
Cytokines
Deoxyribonucleic acid
DNA
Endoscopy
Gallbladder diseases
HMGB1
Hospitals
Infections
Inflammation
interleukin 10
Interleukins
Original Research
Pathogenesis
Patients
Polymerase chain reaction
Proteins
Sepsis
Signal transduction
Surgery
TNF-alpha
Tumor necrosis factor
Tumor necrosis factor-TNF
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container_title Journal of inflammation research
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creator Singh, Akanand
Feng, Yi
Mahato, Nisha
Li, Jinzheng
Wu, Chuanxin
Gong, Jianping
description High-mobility group box 1 (HMGB1) is a proinflammatory cytokine that plays an active role during the pathogenesis of inflammatory processes. The primary aim of this study was to detect whether HMGB1 is involved in the pathogenesis of acute obstructive suppurative cholangitis (AOSC). We collected peripheral blood samples from 23 patients with AOSC and 23 healthy volunteers who served as normal controls. All participants were tested for HMGB1 mRNA level, HMGB1 protein, tumor necrosis factor alpha (TNF-alpha), and interleukin 10 (IL-10). HMGB1 mRNA levels were tested using real-time polymerase chain reaction. HMGB1 protein expression was measured using Western blot. TNF-alpha and IL-10 were tested using enzyme-linked immunosorbent assay. The expression of HMGB1 mRNA and HMGB1 protein was higher in the AOSC group than in the normal controls (P
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The primary aim of this study was to detect whether HMGB1 is involved in the pathogenesis of acute obstructive suppurative cholangitis (AOSC). We collected peripheral blood samples from 23 patients with AOSC and 23 healthy volunteers who served as normal controls. All participants were tested for HMGB1 mRNA level, HMGB1 protein, tumor necrosis factor alpha (TNF-alpha), and interleukin 10 (IL-10). HMGB1 mRNA levels were tested using real-time polymerase chain reaction. HMGB1 protein expression was measured using Western blot. TNF-alpha and IL-10 were tested using enzyme-linked immunosorbent assay. The expression of HMGB1 mRNA and HMGB1 protein was higher in the AOSC group than in the normal controls (P&lt;0.01), and the levels gradually decreased to normal after treatment of the disease (P&lt;0.01). The content of TNF-alpha and IL-10 in peripheral blood of patients with AOSC was significantly higher than that of normal controls (P&lt;0.01) but decreased to normal levels after the necessary treatment (P&lt;0.01). The levels of HMGB1 mRNA and HMGB1 protein were elevated in patients with AOSC, which may play an important role in the inflammation of the bile duct and appears to be associated with the development of sepsis. 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subjects AOSC
Appendicitis
Cholangitis
Chromosomal proteins
Cytokines
Deoxyribonucleic acid
DNA
Endoscopy
Gallbladder diseases
HMGB1
Hospitals
Infections
Inflammation
interleukin 10
Interleukins
Original Research
Pathogenesis
Patients
Polymerase chain reaction
Proteins
Sepsis
Signal transduction
Surgery
TNF-alpha
Tumor necrosis factor
Tumor necrosis factor-TNF
title Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis
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