Clinical usefulness of glycated albumin and glycated albumin-to-glycated hemoglobin ratio of gestational diabetes mellitus in late pregnancy for predicting infant complications

Gestational diabetes mellitus (GDM) with poorly controlled glycemia is associated with poor pregnancy outcomes. However, adequate markers for glycemic control in GDM have not been fully evaluated. We retrospectively studied 77 patients with GDM and their infants. Mean glycated albumin (GA), glycated...

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Published in:Pediatrics and neonatology 2022-05, Vol.63 (3), p.239-246
Main Authors: Sugawara, Daisuke, Sato, Hiroaki, Makita, Eishi, Kuwata, Tomoyuki, Takagi, Kenjiro, Ichihashi, Ko
Format: Article
Language:English
Subjects:
gestationaldiabetes
glycated albumin
glycated albumin/glycated hemoglobin
infant of diabetic mother
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Summary:Gestational diabetes mellitus (GDM) with poorly controlled glycemia is associated with poor pregnancy outcomes. However, adequate markers for glycemic control in GDM have not been fully evaluated. We retrospectively studied 77 patients with GDM and their infants. Mean glycated albumin (GA), glycated hemoglobin (HbA1c), and GA/HbA1c in GDM were compared between two groups stratified by the presence or absence of infant complications (complications or non-complications). We assessed the predictability of infant complications in GA, HbA1c, and GA/HbA1c of women with GDM by receiver operating characteristic analysis (ROC). In complications and non-complications, GA and GA/HbA1c were significantly associated with neonatal hypoglycemia (13.9% vs. 13.0%, p 
ISSN:1875-9572
DOI:10.1016/j.pedneo.2021.10.007