Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease

Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as the most reliable analytic parameter for monitoring t...

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Bibliographic Details
Published in:Allergology international 2008, Vol.57 (4), p.313-320
Main Authors: Taniguchi, Masami, Higashi, Noritaka, Ono, Emiko, Mita, Haruhisa, Akiyama, Kazuo
Format: Article
Language:English
Subjects:
anaphylaxis
Aspirin - immunology
aspirin-intolerant asthma (AIA)
Asthma - complications
Asthma - immunology
Asthma - pathology
Asthma - physiopathology
Biomarkers - urine
Cell Movement - immunology
Churg-Strauss syndrome (CSS)
cysteinyl leukotrienes (CysLTs)
Drug Hypersensitivity - complications
Drug Hypersensitivity - immunology
Drug Hypersensitivity - pathology
Drug Hypersensitivity - physiopathology
Eosinophils - immunology
Eosinophils - metabolism
Eosinophils - pathology
Gene Expression Regulation - immunology
Inflammation
Leukotriene E4 - immunology
Leukotriene E4 - metabolism
Leukotriene E4 - urine
nasal polyp
Nasal Polyps - complications
Nasal Polyps - immunology
Nasal Polyps - pathology
Nasal Polyps - physiopathology
Risk Factors
Vasculitis - complications
Vasculitis - immunology
Vasculitis - pathology
Vasculitis - physiopathology
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Summary:Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as the most reliable analytic parameter for monitoring the endogenous synthesis of CysLTs. From recent studies on the U-LTE4 associated with adult stable asthma we identified four factors for hyperleukotrieneuria, namely, aspirin intolerance, eosinophilic nasal polyposis (ENP), vasculitis, and severe asthma. In ENP, there is prominent infiltration of eosinophils in the sinus and polyp tissues, which is linked to adult asthma and aspirin sensitivity, and ENP is the most important factor for the overproduction of CysLTs in asthmatics. We also demonstrated that anaphylaxis and eosinophilic pneumonia (EP) are associated with a marked increase in the U-LTE4 concentration. Under these disease conditions, U-LTE4 may be one of the candidate biomarkers. Moreover, the changes in U-LTE4 concentrations may provide valuable information concerning therapeutic targets.
ISSN:1323-8930
1440-1592
DOI:10.2332/allergolint.08-RAI-0040