Regulation of Necroptosis by Phospholipids and Sphingolipids

Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggest...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-03, Vol.9 (3), p.627
Main Authors: Zhang, Xuewei, Matsuda, Masaya, Yaegashi, Nobuo, Nabe, Takeshi, Kitatani, Kazuyuki
Format: Article
Language:English
Subjects:
Animals
ceramide
Ceramides - genetics
Ceramides - metabolism
fatty acids
Humans
lipids
mixed lineage kinase-domain like
necroptosis
Necroptosis - physiology
phosphatidylinositols
Phospholipids - metabolism
Protein Kinases - metabolism
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Review
Sphingolipids - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9030627