Identification of genetic loci shared between schizophrenia and the Big Five personality traits

Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistica...

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Bibliographic Details
Published in:Scientific reports 2017-05, Vol.7 (1), p.2222-9, Article 2222
Main Authors: Smeland, Olav B., Wang, Yunpeng, Lo, Min-Tzu, Li, Wen, Frei, Oleksandr, Witoelar, Aree, Tesli, Martin, Hinds, David A., Tung, Joyce Y., Djurovic, Srdjan, Chen, Chi-Hua, Dale, Anders M., Andreassen, Ole A.
Format: Article
Language:English
Subjects:
45
45/43
631/208/205/2138
631/477/2811
692/699/476/1799
Bayesian analysis
Etiology
Gene loci
Genetic Association Studies
Genetic diversity
Genetic Loci
Genetic Predisposition to Disease
Genetic variance
Genome-wide association studies
Humanities and Social Sciences
Humans
Mental disorders
multidisciplinary
Neurosis
Personality
Personality - genetics
Personality traits
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
Schizophrenia
Schizophrenia - genetics
Schizophrenic Psychology
Science
Science (multidisciplinary)
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Summary:Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-02346-3