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Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study
Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program. We performed a 24-week randomized controlled feasibility study comparing aerobic exercise plus optimal medical management to medi...
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Published in: | Cardiovascular diabetology 2009-12, Vol.8 (1), p.62-62 |
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creator | Leehey, David J Moinuddin, Irfan Bast, Joseph P Qureshi, Shahzad Jelinek, Christine S Cooper, Cheryl Edwards, Lonnie C Smith, Bridget M Collins, Eileen G |
description | Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program.
We performed a 24-week randomized controlled feasibility study comparing aerobic exercise plus optimal medical management to medical management alone in patients with type 2 diabetes, obesity (body mass index [BMI] > 30 kg/m2), and stage 2-4 CKD (estimated glomerular filtration rate [eGFR] 15-90 mL/min/1.73 m2 with persistent proteinuria). Subjects randomized to exercise underwent thrice weekly aerobic training for 6 followed by 18 weeks of supervised home exercise. The primary outcome variable was change in proteinuria.
Seven subjects randomized to exercise and 4 control subjects completed the study. Exercise training resulted in an increase in exercise duration during treadmill testing, which was accompanied by slight but insignificant decreases in resting systolic blood pressure and 24-hour proteinuria. Exercise did not alter GFR, hemoglobin, glycated hemoglobin, serum lipids, or C-reactive protein (CRP). Caloric intake and body weight and composition also did not change with exercise training.
Exercise training in obese diabetic patients with CKD is feasible and may have clinical benefits. A large-scale randomized controlled trial to determine the effects of exercise on renal functions, cardiovascular fitness, inflammation, and oxidative stress in diabetic patients with CKD is planned. |
doi_str_mv | 10.1186/1475-2840-8-62 |
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We performed a 24-week randomized controlled feasibility study comparing aerobic exercise plus optimal medical management to medical management alone in patients with type 2 diabetes, obesity (body mass index [BMI] > 30 kg/m2), and stage 2-4 CKD (estimated glomerular filtration rate [eGFR] 15-90 mL/min/1.73 m2 with persistent proteinuria). Subjects randomized to exercise underwent thrice weekly aerobic training for 6 followed by 18 weeks of supervised home exercise. The primary outcome variable was change in proteinuria.
Seven subjects randomized to exercise and 4 control subjects completed the study. Exercise training resulted in an increase in exercise duration during treadmill testing, which was accompanied by slight but insignificant decreases in resting systolic blood pressure and 24-hour proteinuria. Exercise did not alter GFR, hemoglobin, glycated hemoglobin, serum lipids, or C-reactive protein (CRP). Caloric intake and body weight and composition also did not change with exercise training.
Exercise training in obese diabetic patients with CKD is feasible and may have clinical benefits. A large-scale randomized controlled trial to determine the effects of exercise on renal functions, cardiovascular fitness, inflammation, and oxidative stress in diabetic patients with CKD is planned.</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/1475-2840-8-62</identifier><identifier>PMID: 20003224</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers - blood ; Blood Pressure ; Body Composition ; Body Mass Index ; C-Reactive Protein - metabolism ; Chronic Disease ; Creatinine - blood ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - therapy ; Diabetic Nephropathies - etiology ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - therapy ; Energy Intake ; Exercise Therapy ; Exercise Tolerance ; Feasibility Studies ; Glomerular Filtration Rate ; Heart Rate ; Hemoglobins - metabolism ; Humans ; Kidney - physiopathology ; Lipids - blood ; Male ; Middle Aged ; Obesity - complications ; Obesity - physiopathology ; Obesity - therapy ; Original investigation ; Oxygen Consumption ; Pilot Projects ; Proteinuria - etiology ; Proteinuria - therapy ; Time Factors ; Treatment Outcome</subject><ispartof>Cardiovascular diabetology, 2009-12, Vol.8 (1), p.62-62</ispartof><rights>Copyright ©2009 Leehey et al; licensee BioMed Central Ltd. 2009 Leehey et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796994/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796994/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20003224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leehey, David J</creatorcontrib><creatorcontrib>Moinuddin, Irfan</creatorcontrib><creatorcontrib>Bast, Joseph P</creatorcontrib><creatorcontrib>Qureshi, Shahzad</creatorcontrib><creatorcontrib>Jelinek, Christine S</creatorcontrib><creatorcontrib>Cooper, Cheryl</creatorcontrib><creatorcontrib>Edwards, Lonnie C</creatorcontrib><creatorcontrib>Smith, Bridget M</creatorcontrib><creatorcontrib>Collins, Eileen G</creatorcontrib><title>Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study</title><title>Cardiovascular diabetology</title><addtitle>Cardiovasc Diabetol</addtitle><description>Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program.
We performed a 24-week randomized controlled feasibility study comparing aerobic exercise plus optimal medical management to medical management alone in patients with type 2 diabetes, obesity (body mass index [BMI] > 30 kg/m2), and stage 2-4 CKD (estimated glomerular filtration rate [eGFR] 15-90 mL/min/1.73 m2 with persistent proteinuria). Subjects randomized to exercise underwent thrice weekly aerobic training for 6 followed by 18 weeks of supervised home exercise. The primary outcome variable was change in proteinuria.
Seven subjects randomized to exercise and 4 control subjects completed the study. Exercise training resulted in an increase in exercise duration during treadmill testing, which was accompanied by slight but insignificant decreases in resting systolic blood pressure and 24-hour proteinuria. Exercise did not alter GFR, hemoglobin, glycated hemoglobin, serum lipids, or C-reactive protein (CRP). Caloric intake and body weight and composition also did not change with exercise training.
Exercise training in obese diabetic patients with CKD is feasible and may have clinical benefits. A large-scale randomized controlled trial to determine the effects of exercise on renal functions, cardiovascular fitness, inflammation, and oxidative stress in diabetic patients with CKD is planned.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Blood Pressure</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - metabolism</subject><subject>Chronic Disease</subject><subject>Creatinine - blood</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - therapy</subject><subject>Energy Intake</subject><subject>Exercise Therapy</subject><subject>Exercise Tolerance</subject><subject>Feasibility Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Heart Rate</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Original investigation</subject><subject>Oxygen Consumption</subject><subject>Pilot Projects</subject><subject>Proteinuria - etiology</subject><subject>Proteinuria - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1475-2840</issn><issn>1475-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kkFv1DAQhSMEoqVw5Yh845RiO05sc0BaVRQqVeICZ2tij7suSRzsbGH59fWyZdUV4uTnmadvPJ6pqteMnjOmundMyLbmStBa1R1_Up0eAk8f6ZPqRc63lDKpOva8OuGU0oZzcVrNK0yxD5bgL0w2ZCRhIrHHIlyAHpeSmmEJOC2Z_AzLmth1ilOJfg9uwm1xZYSM7wmQBJOLY_iNjhRFbJyWFIehXOcwxIXkZeO2L6tnHoaMrx7Os-rb5cevF5_r6y-fri5W13XfUrnUrkGmtWSNR0a19Z52momm7TtpATUA80JQUB7BttJ75XnrPFgqQELH--asutpzXYRbM6cwQtqaCMH8CcR0YyCV7gY0UjmteuQtMCuk1doqab1VjMmGl_KF9WHPmjf9iM6Wz0gwHEGPM1NYm5t4Z7jUndaiAFZ7QB_ifwDHGRtHs5ue2U3PKNPxwnj78IgUf2wwL2YM2eIwwIRxk41sBKetZro4z_dOm2LOCf2hEKNmtzX_ot887u9g_7smzT2458DV</recordid><startdate>20091209</startdate><enddate>20091209</enddate><creator>Leehey, David J</creator><creator>Moinuddin, Irfan</creator><creator>Bast, Joseph P</creator><creator>Qureshi, Shahzad</creator><creator>Jelinek, Christine S</creator><creator>Cooper, Cheryl</creator><creator>Edwards, Lonnie C</creator><creator>Smith, Bridget M</creator><creator>Collins, Eileen G</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20091209</creationdate><title>Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study</title><author>Leehey, David J ; Moinuddin, Irfan ; Bast, Joseph P ; Qureshi, Shahzad ; Jelinek, Christine S ; Cooper, Cheryl ; Edwards, Lonnie C ; Smith, Bridget M ; Collins, Eileen G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-d3e199713fe109cff0691435b67cae9aa1f440a8feac57ff8f25dfac04a7a62b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - metabolism</topic><topic>Chronic Disease</topic><topic>Creatinine - blood</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diabetic Nephropathies - etiology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - therapy</topic><topic>Energy Intake</topic><topic>Exercise Therapy</topic><topic>Exercise Tolerance</topic><topic>Feasibility Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Heart Rate</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Original investigation</topic><topic>Oxygen Consumption</topic><topic>Pilot Projects</topic><topic>Proteinuria - etiology</topic><topic>Proteinuria - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leehey, David J</creatorcontrib><creatorcontrib>Moinuddin, Irfan</creatorcontrib><creatorcontrib>Bast, Joseph P</creatorcontrib><creatorcontrib>Qureshi, Shahzad</creatorcontrib><creatorcontrib>Jelinek, Christine S</creatorcontrib><creatorcontrib>Cooper, Cheryl</creatorcontrib><creatorcontrib>Edwards, Lonnie C</creatorcontrib><creatorcontrib>Smith, Bridget M</creatorcontrib><creatorcontrib>Collins, Eileen G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Cardiovascular diabetology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leehey, David J</au><au>Moinuddin, Irfan</au><au>Bast, Joseph P</au><au>Qureshi, Shahzad</au><au>Jelinek, Christine S</au><au>Cooper, Cheryl</au><au>Edwards, Lonnie C</au><au>Smith, Bridget M</au><au>Collins, Eileen G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study</atitle><jtitle>Cardiovascular diabetology</jtitle><addtitle>Cardiovasc Diabetol</addtitle><date>2009-12-09</date><risdate>2009</risdate><volume>8</volume><issue>1</issue><spage>62</spage><epage>62</epage><pages>62-62</pages><issn>1475-2840</issn><eissn>1475-2840</eissn><abstract>Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program.
We performed a 24-week randomized controlled feasibility study comparing aerobic exercise plus optimal medical management to medical management alone in patients with type 2 diabetes, obesity (body mass index [BMI] > 30 kg/m2), and stage 2-4 CKD (estimated glomerular filtration rate [eGFR] 15-90 mL/min/1.73 m2 with persistent proteinuria). Subjects randomized to exercise underwent thrice weekly aerobic training for 6 followed by 18 weeks of supervised home exercise. The primary outcome variable was change in proteinuria.
Seven subjects randomized to exercise and 4 control subjects completed the study. Exercise training resulted in an increase in exercise duration during treadmill testing, which was accompanied by slight but insignificant decreases in resting systolic blood pressure and 24-hour proteinuria. Exercise did not alter GFR, hemoglobin, glycated hemoglobin, serum lipids, or C-reactive protein (CRP). Caloric intake and body weight and composition also did not change with exercise training.
Exercise training in obese diabetic patients with CKD is feasible and may have clinical benefits. A large-scale randomized controlled trial to determine the effects of exercise on renal functions, cardiovascular fitness, inflammation, and oxidative stress in diabetic patients with CKD is planned.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>20003224</pmid><doi>10.1186/1475-2840-8-62</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Biomarkers - blood Blood Pressure Body Composition Body Mass Index C-Reactive Protein - metabolism Chronic Disease Creatinine - blood Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Diabetic Nephropathies - etiology Diabetic Nephropathies - physiopathology Diabetic Nephropathies - therapy Energy Intake Exercise Therapy Exercise Tolerance Feasibility Studies Glomerular Filtration Rate Heart Rate Hemoglobins - metabolism Humans Kidney - physiopathology Lipids - blood Male Middle Aged Obesity - complications Obesity - physiopathology Obesity - therapy Original investigation Oxygen Consumption Pilot Projects Proteinuria - etiology Proteinuria - therapy Time Factors Treatment Outcome |
title | Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study |
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