Do components of adult height predict body composition and cardiometabolic risk in a young adult South Asian Indian population? Findings from a hospital-based cohort study in Pune, India: Pune Children’s Study

• Published in: BMJ open 2020-10, Vol.10 (10), p.e036897-e036897
• Main Authors: Kumaran, Kalyanaraman, Joshi, Suyog M, Di Gravio, Chiara, Lubree, Himangi, Joglekar, Charudatta, Bhat, Dattatray, Kinare, Arun, Bavdekar, Ashish, Bhave, Sheila, Pandit, Anand, Osmond, Clive, Yajnik, Chittaranjan, Fall, Caroline
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Age; Body Composition; Body fat; Body Height; Body Mass Index; cardiac epidemiology; Cardiovascular Diseases - epidemiology; Child; Cholesterol; Cohort analysis; Cohort Studies; Cross-Sectional Studies; Diabetes; diabetes and endocrinology; Epidemiology; Glucose; Hospitals; Humans; India - epidemiology; Insulin resistance; Investigations; Low income groups; Plasma; preventive medicine; Risk factors; Socioeconomic factors; Women; Young Adult; Young adults
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2020-036897

ObjectivesWe investigated whether the relationship between components of height and cardiovascular disease (CVD) risk may be explained by body composition. We also examined relationships between parental heights and offspring CVD risk.DesignA cohort study using cross-sectional data.SettingA secondary care hospital setting in Pune, India.ParticipantsWe studied 357 young adults and their parents in the Pune Children’s Study. Primary and secondary outcomes: we measured weight, total height, leg length, sitting height, plasma glucose, insulin and lipids, and blood pressure (BP). Total and regional lean and fat mass were measured by dual X-ray absorptiometry.ResultsLeg length was inversely related, and sitting height was directly related to BMI. Total height and leg length were directly related to lean mass, while sitting height was directly related to both lean and fat mass. Leg length was inversely related to systolic BP and 120 min glucose, independent of lean and fat mass. Sitting height was directly related to systolic BP and triglycerides; these relationships were attenuated on adjustment for lean and fat mass. When examined simultaneously, greater leg length was protective and greater sitting height was associated with a more detrimental CVD risk profile.ConclusionsShorter adult leg length and greater sitting height are associated with a more adverse CVD risk factor profile. The mechanisms need further study, but our findings suggest a role for lean and fat mass.