Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putati...

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Bibliographic Details
Published in:Genome Biology 2021-08, Vol.22 (1), p.242-242, Article 242
Main Authors: Kasela, Silva, Daniloski, Zharko, Bollepalli, Sailalitha, Jordan, Tristan X, tenOever, Benjamin R, Sanjana, Neville E, Lappalainen, Tuuli
Format: Article
Language:English
Subjects:
Chromosome 3
Chromosomes, Human, Pair 3 - genetics
Coronaviruses
COVID-19
COVID-19 - genetics
CRISPR
Disease
eQTL
Gene expression
Genomes
GWAS
Hospitalization
Humans
Infections
Membrane Transport Proteins - genetics
Pathogens
Phenotype
Proteins
Quantitative Trait Loci
Receptors, CXCR6 - genetics
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Short Report
Viral infections
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Summary:To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.
ISSN:1474-760X
1474-7596
1474-760X
DOI:10.1186/s13059-021-02454-4