Comparison of Cortical Autonomic Network-Linked Sympathetic Excitation by Mueller Maneuvers and Breath-Holds in Subjects With and Without Obstructive Sleep Apnea

In healthy young volunteers, acquisition of blood oxygen level-dependent (BOLD) magnetic resonance (MR) and muscle sympathetic nerve (MSNA) signals during simulation of obstructive or central sleep apnea identified cortical cardiovascular autonomic regions in which the BOLD signal changed synchronou...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in physiology 2021-05, Vol.12, p.678630-678630
Main Authors: Taylor, Keri S., Keir, Daniel A., Haruki, Nobuhiko, Kimmerly, Derek S., Millar, Philip J., Murai, Hisayoshi, Floras, John S.
Format: Article
Language:English
Subjects:
breath hold
functional magnetic resonance imaging (fMRI)
Mueller maneuver
Physiology
sleep apnea
sympathetic nerve activity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In healthy young volunteers, acquisition of blood oxygen level-dependent (BOLD) magnetic resonance (MR) and muscle sympathetic nerve (MSNA) signals during simulation of obstructive or central sleep apnea identified cortical cardiovascular autonomic regions in which the BOLD signal changed synchronously with acute noradrenergic excitation. In the present work, we tested the hypothesis that such Mueller maneuvers (MM) and breath-holds (BH) would elicit greater concomitant changes in mean efferent nerve firing and BOLD signal intensity in patients with moderate to severe obstructive sleep apnea (OSA) relative to age- and sex-matched individuals with no or only mild OSA (Apnea Hypopnea Index, AHI,
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2021.678630